Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity

Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and Log D lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG.

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