کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371739 | 981853 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. The synthesis, SAR and biological profiles of the series are described.
Utilizing a high-throughput screening lead as a starting point, an information-based approach led to the discovery of a novel series of CCR5 antagonists, exemplified by compound 4. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. The synthesis, SAR and biological profiles of the series are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 10, 15 May 2010, Pages 3116–3119
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 10, 15 May 2010, Pages 3116–3119
نویسندگان
David M. Rotstein, Chris R. Melville, Fernando Padilla, Dick Cournoyer, Eun K. Lee, Remy Lemoine, Ann C. Petersen, Lina Q. Setti, Jutta Wanner, Lijing Chen, Lubov Filonova, David G. Loughhead, Jason Manka, Xiao-Fa Lin, Shelley Gleason, Surya Sankuratri,