کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371957 | 981860 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of a new series of 5-HT1A receptor agonists
ترجمه فارسی عنوان
کشف یک سری جدید از آگونیست های گیرنده 5-HT1A
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کلمات کلیدی
گیرنده 5-HT1A؛ آگونیست؛ 1،3-دیاکسولان؛ حسن انتخاب
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Starting from compounds previously identified as α1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have high potency and/or high selectivity. Of these, compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting.
A new series of 5-HT1A receptor agonists has been discovered. Compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting of the series.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 6, 15 March 2010, Pages 2017–2020
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 6, 15 March 2010, Pages 2017–2020
نویسندگان
Silvia Franchini, Adolfo Prandi, Claudia Sorbi, Annalisa Tait, Annamaria Baraldi, Piero Angeli, Michela Buccioni, Antonio Cilia, Elena Poggesi, Paola Fossa, Livio Brasili,