کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371976 981863 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
چکیده انگلیسی

Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published MMP-13 inhibitors. Potency and selectivity were improved by extending the hit structure out from the active site into the S1′ pocket.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5321–5324
نویسندگان
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