کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371979 981863 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
چکیده انگلیسی

A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Nav1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement on Nav1.7 inhibitory activity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5334–5338
نویسندگان
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