Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARα agonists

Bis-oximinoalkanoic acid derivatives were designed and synthesized to aid in the characterization of selective PPARα agonists by replacing the oxazole ring with flexible oximino group in the lipophilic tail part of a previously reported compound 3. Selected compounds 9d and 9m showed excellent potency and high selectivity towards PPARα in vitro. These compounds found effective in reducing serum triglycerides (TG) in vivo.

A novel class of selective PPARα agonists containing bis-oximinoalkanoic acid was described. Selected compounds 9d and 9m showed excellent potency and high selectivity towards PPARα in vitro and found to be effective in reducing serum triglycerides (TG) in vivo.Figure optionsDownload as PowerPoint slide