کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372146 981866 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel antileukemic agents derived from tamibarotene and nitric oxide donors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel antileukemic agents derived from tamibarotene and nitric oxide donors
چکیده انگلیسی

A series of novel nitric oxide-releasing tamibarotene derivatives were synthesized by coupling nitric oxide (NO) donors with tamibarotene via various spacers, and were evaluated for their antiproliferative activities against human leukemic HL-60, NB4 and K562 cell lines in vitro. The test results showed that three compounds (7g, 9a and 9e) exhibited more potent antileukemic activity than the control tamibarotene. Furthermore, the preliminary structure–activity analysis revealed that amino acids serving as spacers could bring about significantly improved biological activities of NO donor hybrids. These interesting results could provide new insights into the development of NO-based antileukemic agents.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 23, 1 December 2011, Pages 7025–7029
نویسندگان
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