کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372156 | 981866 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered.
The design and synthesis of a novel series of c-jun N-terminal kinase (JNK) inhibitors is described. The development of the 2-phenoxypyridine series was discovered from an earlier pyrimidine series of JNK inhibitors. Through the optimization of the scaffold 5, several potent compounds with good in vivo profiles were developed.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 23, 1 December 2011, Pages 7072–7075
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 23, 1 December 2011, Pages 7072–7075
نویسندگان
Xinyi Song, Weimin Chen, Li Lin, Claudia H. Ruiz, Michael D. Cameron, Derek R. Duckett, Theodore M. Kamenecka,