کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372320 981868 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry
چکیده انگلیسی

STAT3 (Signal Transducer and Activator of Transcription factor 3) is constitutively active in a wide range of human tumours. Stattic is one of the first non-peptidic small molecules reported to inhibit formation of the STAT3:STAT3 protein dimer complex. A mass spectrometry method has been developed to investigate the binding of Stattic to the un-phosphorylated STAT3βtc (U-STAT3) protein. Alkylation of four cysteine residues has been observed with possible reaction at a fifth which could account for the mechanism of action.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 16, 15 August 2013, Pages 4719–4722
نویسندگان
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