کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372560 981871 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells
چکیده انگلیسی

Cannabinoid CB2 receptor has emerged as a very promising target over the last decades. We have synthesized and evaluated a new fluorescent probe designated NMP6 based on 6-methoxyisatin scaffold, which exhibited selectivity and Ki value at hCB2 of 387 nM. We have demonstrated its ability to be an effective probe for visualization of CB2 receptor binding using confocal microscopy and a flow cytometry probe for the analysis of CB2 protein expression. Furthermore, NMP6 was easily obtained in two chemical steps from commercially available building blocks.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 19, 1 October 2011, Pages 5859–5862
نویسندگان
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