کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372660 981878 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
چکیده انگلیسی

A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.

A series of 2-amino-isoxazolopyridine analogs was identified as inhibitors of Polo-like kinase (Plk). Co-crystal structures of inhibitors with Plk demonstrate key binding motifs. Differential selectivity among the three Plk isoforms is observed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 19, 1 October 2008, Pages 5186–5189
نویسندگان
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