کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372790 981881 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studies
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studies
چکیده انگلیسی

Twenty-two pyrazoline derivatives were synthesized and tested for their human MAO (hMAO) inhibitory activity. Twelve molecules with unsubstituted ring A and substituted ring C (5–16) were found to be potent inhibitors of hMAO-A isoform with SIMAO-A in the order 103 and 104. Ten molecules with unsubstituted ring A and without ring C (21–30), in which eight molecules (21, 23–26, and 28–30) were selective for hMAO-A, one for hMAO-B (22) and the other one non-selective (27). Presence of ring C increases potency as well as SI towards hMAO-A; however its absence decreases both potency and SI towards hMAO-A and hMAO-B.

Pyrazoline derivatives with unsubstituted ring A and substituted ring C (5–16) were found to be potent inhibitors of MAO-A isoform with SIMAO-A in the order of 103 and 104.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 14, 15 July 2011, Pages 4296–4300
نویسندگان
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