کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372829 981882 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors
چکیده انگلیسی

A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure–activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.

A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure–activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 17, 1 September 2008, Pages 4844–4848
نویسندگان
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