کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372836 | 981882 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis](/preview/png/1372836.png)
We have prepared a novel speculative eight-membered lactam demonstration library based on the skeletal structure of the potent antitumor marine natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via ring-closing metathesis chemistry from the corresponding diene amides. A cursory examination of the biological properties of the library validates the relevance and significance of these structures.
We have prepared a novel speculative eight-membered lactam demonstration library inspired by the antitumor natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via RCM from the corresponding diene amides. A cursory examination of the biological properties of the library validates the relevance and significance of these structures.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 17, 1 September 2008, Pages 4876–4879