Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis

Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol % l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation.

Hybrid liposomes composed of 90 mol % l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(n) dodecyl ethers (C12(EO)n) could selectively accumulate into adult T-cell leukemia (ATL) cells and induce apoptosis via caspase-3 activation.Figure optionsDownload as PowerPoint slide