کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372953 | 981886 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design driven HtL: The discovery and synthesis of new high efficacy β2-agonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The design and synthesis of a new series of high efficacy β2-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β2-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β2-adrenoceptor crystal structure, other biophysical data and modeling studies.
The design and synthesis of a new series of high efficacy β2-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β2-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β2AR crystal structure, other biophysical data and modeling studies.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 4027–4031
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 4027–4031
نویسندگان
Michael J. Stocks, Lilian Alcaraz, Andrew Bailey, Roger Bonnert, Elaine Cadogan, Jadeen Christie, Stephen Connolly, Anthony Cook, Adrian Fisher, Alice Flaherty, Stephen Hill, Alexander Humphries, Anthony Ingall, Stephen Jordan, Mandy Lawson, Alex Mullen,