کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372998 981887 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase
چکیده انگلیسی

We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhibit good inhibition activity and excellent kinase selectivity.

We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhibit good inhibition activity and excellent kinase selectivity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 4, 15 February 2013, Pages 1046–1050
نویسندگان
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