کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373004 | 981887 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pentacyclic hemiacetal sterol with antifouling and cytotoxic activities from the soft coral Nephthea sp.
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pentacyclic hemiacetal sterol with antifouling and cytotoxic activities from the soft coral Nephthea sp. Pentacyclic hemiacetal sterol with antifouling and cytotoxic activities from the soft coral Nephthea sp.](/preview/png/1373004.png)
چکیده انگلیسی
A novel unusual pentacyclic hemiacetal sterol nephthoacetal (1), was isolated from soft coral Nephthea sp. The structure of this sterol was inferred from its two acetyl derivatives (2) and (3), by means of spectroscopic methods, and quantum chemical calculations. Anti-fouling activity of compounds 1–3 against Bugula neritina larvae was evaluated, sterol (1) exhibited significant inhibitory effect with EC50 value of 2.5 μg/mL, while having low toxicity with LC50 >25.0 μg/mL. The in vitro cytotoxic activity of compounds 1–3 against HeLa cells was also evaluated, all of them exhibited moderate cytotoxicity with IC50 values of 12.3 (1), 10.1 (2), and 19.6 μg/mL (3), respectively.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 4, 15 February 2013, Pages 1079–1082
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 4, 15 February 2013, Pages 1079–1082
نویسندگان
Jun Zhang, Liang-Chun Li, Kai-Ling Wang, Xiao-Jian Liao, Zhou Deng, Shi-Hai Xu,