کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373108 | 981890 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
First stereoselective total synthesis and anticancer activity of new amide alkaloids of roots of pepper
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: First stereoselective total synthesis and anticancer activity of new amide alkaloids of roots of pepper First stereoselective total synthesis and anticancer activity of new amide alkaloids of roots of pepper](/preview/png/1373108.png)
چکیده انگلیسی
The first stereoselective total synthesis of new natural amide alkaloids 1–3 have been achieved from commercially available starting materials. Wittig olefination, Sharpless asymmetric dihydroxylation, epoxidation, a trans regioselective opening of 2,3-epoxy alcohol, Horner–Wadsworth–Emmons (HWE) olefination and amide coupling are the key steps. The amide alkaloids 1–3 are evaluated for their anticancer activity against colon (HT-29), breast (MCF-7) and lung (A-549) human cancer cell lines for the first time.
The first stereoselective total synthesis of new natural amide alkaloids 1–3 and their anti cancer activity is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 20, 15 October 2009, Pages 5915–5918
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 20, 15 October 2009, Pages 5915–5918
نویسندگان
Ch. Srinivas, Ch.N.S. Sai Pavan Kumar, B. China Raju, V. Jayathirtha Rao, V.G.M. Naidu, S. Ramakrishna, Prakash V. Diwan,