کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373215 | 981893 | 2007 | 4 صفحه PDF | دانلود رایگان |

Vitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.
Vitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 22, 15 November 2007, Pages 6151–6154