کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373215 981893 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides
چکیده انگلیسی

Vitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.

Vitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 22, 15 November 2007, Pages 6151–6154
نویسندگان
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