کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1373296 | 981895 | 2009 | 4 صفحه PDF | دانلود رایگان |

The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI’s in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.
The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI’s in vitro 60 human tumor cell lines. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4643–4646