کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373304 981895 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ulmosides A and B: Flavonoid 6-C-glycosides from Ulmuswallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Ulmosides A and B: Flavonoid 6-C-glycosides from Ulmuswallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase
چکیده انگلیسی

Chemical investigation of Ulmus wallichiana stem bark resulted in isolation and identification of three new compounds (2S,3S)-(+)-3′,4′,5,7-tetrahydroxydihydroflavonol-6-C-β-d-glucopyranoside (1), (2S,3S)-(+)-4′,5,7-trihydroxydihydroflavonol-6-C-β-d-glucopyranoside (3) and 3-C-β-d-glucopyranoside-2,4,6-trihydroxymethylbenzoate (8), together with five known flavonoid-6-C-glucosides (2, 4–7). Their structures were elucidated using 1D and 2D NMR spectroscopic analysis. The absolute stereochemistry in compounds 1 and 3 were established with the help of CD data analysis and comparison with the literature data analysis. All the isolated compounds (1–8) were assessed for promoting the osteoblast differentiation using primary culture of rat osteoblast as an in vitro system. Compounds 1–3 and 5 significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity.

Three new compounds, ulmoside A (1) ulmoside B (3) and ulmoside C (8) along with five known compounds were isolated from Ulmus wallichiana. Compounds 1-3 and 5 showed promising osteogenic activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4684–4687
نویسندگان
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