کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373385 1500544 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate
چکیده انگلیسی

We determined the experimental solubility of CNS marketed drugs. Of the 98 drugs measured, greater than 90% had solubility >10 μM in pH 7.4 buffer. Only seven drugs had solubility <10 μM. Using these data, we established a solubility criterion to support CNS discovery. The implication of poor solubility with potential safety concerns and undesirable side effects are discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 24, 15 December 2010, Pages 7312–7316
نویسندگان
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