Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide–alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.

A series of triazoloacyclic nucleoside phosphonates were synthesized and evaluated for their in vitro antiviral activities (HCV and HIV) and cytotoxicities.Figure optionsDownload as PowerPoint slide