Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium

The phytochemical investigation of the hexane extract of the Hedychium coronarium led to the isolation and identification of two new labdane diterpenes (1 and 2) along with 10 known metabolites (3–12). The structures of the new compounds were established on the basis of spectroscopic data analysis (1D and 2D NMR and MS). Cytotoxic activities of the isolates were studied against the A-549 (lung cancer), SK-N-SH (human neuroblastoma), MCF-7 (breast cancer) and HeLa (cervical cancer) cell lines.

Phytochemical investigation on Hedychium coronarium rhizomes yielded two new labdane diterpenes (1 and 2) along with 10 known compounds (3–12). Cytotoxic activity of the isolates were studied against A-549 (human lung carcinoma) SK-N-SH (human neuroblastma), MCF-7 (breast cancer) and HeLa (cervical cancer) cell lines.Figure optionsDownload as PowerPoint slide