Piperidine-based renin inhibitors: Upper chain optimization

The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor with a suitable profile for development is described.

The optimization of the 4-position of 3,4-disubstituted piperidine-based renin inhibitors is reported herein. This work culminated in the discovery of 11, a renin inhibitor with a suitable profile for development.Figure optionsDownload as PowerPoint slide