کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373568 981903 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
چکیده انگلیسی

The synthesis and in vitro activities of a series of succinyl-nitrile-based inhibitors of Cathepsin S are described. Several members of this class show nanomolar inhibition of the target enzyme as well as cellular potency. The inhibitors displaying the greatest potency contain N-alkyl substituted piperidine and pyrrolidine rings spiro-fused to the α-carbon of the P1 residue.

The synthesis and SAR of the first succinyl-nitrile-based compounds as Cathepsin S inhibitors are described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 9, 1 May 2007, Pages 2465–2469
نویسندگان
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