Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

Eight tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared from d-(+)-glucose. THFD 10 was eqivalent to 14, 15-EET as a vasodilator of pre-contracted bovine arteries.Figure optionsDownload as PowerPoint slide