Keywords: AADAC; arylacetamide deacetylase; AEA; arachidonoyl ethanolamide; EETs; epoxyeicosatrienoic acids; FAAH; fatty acid amide hydrolase; hCE; human carboxylesterase; MAP; methoxy arachidonoyl phosphonate; NSAIDS; non-steroidal anti-inflammatory drugs; PF-3845
مقالات ISI (ترجمه نشده)
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Keywords: RA; rheumatoid arthritis; RF; rheumatoid factor; ACPA; anti-citrullinated protein antibodies; AA; arachidonic acid; PG; prostaglandins; LT; leukotrienes; TX; thromboxanes; LX; lipoxins; NSAID; non steroidal anti-inflammatory drugs; COXIB; COX-2 selective
Keywords: CVDs; cardiovascular diseases; sEH; soluble epoxide hydrolase; MD; molecular dynamics; EETs; epoxyeicosatrienoic acids; DHETs; dihydroxy-eicosatrienoic acids; MM/PBSA; molecular mechanics poisson-boltzmann surface area; ROF; rule of five; NVT; number of p
Keywords: EETs; epoxyeicosatrienoic acids; sEH; soluble epoxide hydrolase; AA; arachidonic acid; DHET; dihydroxyeicosatrienoic acid; Epxh-2; epoxide hydrolase 2; AUDA; 12- [3-adamantane-1-yl-ureido]-dodecanoic acid; MCAO/R; middle cerebral artery occlusion and repe
Keywords: AA; arachidonic acid; DHETs; dihydroxyeicosatrienoic acids; EETs; epoxyeicosatrienoic acids; eNOS; endothelial nitric oxide synthase; l-NAME; NÏ-nitro-l-arginine methyl ester hydrochloride; MS-PPOH; N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide;
Keywords: EETs; epoxyeicosatrienoic acids; sEH; soluble epoxide hydrolase; DHETs; dihydroxyeicosatrienoic acids; t-TUCB; trans-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzoic acid; IHVR; intrahepatic vascular resistance; α-SMA; alpha-smooth muscle a
Keywords: Endocrine recovery; Endoscopic endonasal transsphenoidal surgery; Rathke cleft cyst; Surgical outcome; CSF; Cerebrospinal fluid; DI; Diabetes insipidus; EETS; Endonasal endoscopic transphenoidal surgery; MRI; Magnetic resonance imaging; RCC; Rathke cleft
Keywords: AMPP; N-(4-amiomethylphenyl)pyridinium; aPC; plasmanylcholine; aPE; plasmanylethanolamine; dPC; phosphatidylcholine; dPE; phosphatidylethanolamine; DEGs; differently expressed genes; EETs; epoxyeicosatrienoic acids; 4-HDDE; 4-hydroxy-2E,6Z-dodecadienal; H
Keywords: AD; Alzheimer's disease; ARA; arachidonic acid; COX; cyclooxygenase; CYP450; cytochrome P450; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; EETs; epoxyeicosatrienoic acids; EpFAs; epoxy-fatty acids; ER Stress; endoplasmic reticulum stress; IBD; i
Keywords: sEH; soluble epoxide hydrolase; mEH; microsomal epoxide hydroxylases; EETs; Epoxyeicosatrienoic acids; PD; Parkinson's disease; SNCA; synuclein alpha; LRRK2; leucine-rich repeat kinase 2; PARK2; E3 ubiquitin-protein ligase parkin; PINK1; PTEN induced pu
Keywords: pAKT; pAMPK; Adiponectin; EETs;
Keywords: ÎΨm; mitochondrial membrane potential; AMI; acute myocardial infarction; CAD; coronary artery disease; Cav-1; caveolin-1; Cav-3; caveolin-3; CPR; cardiopulmonary resuscitation; DHETS; dihydroxyeicosatrienoic acids; DHOMEs; dihydroxyoctadecaenoic acids;
Keywords: EETs; epoxyeicosatrienoic acids; sEH; soluble epoxide hydrolase; EDCI; 1-[3-(dimethylamino)propyl]-3-ethyl-carbodiimide; DMAP; 4-dimethylaminopyridine; DMF; N,N-dimethylformamide; CMNPC; cyano-(2-methoxynaphthalen-6-yl)-methyl trans-(3-phenyl-oxyran-2-yl)
Keywords: 20-HETE; 20-hydroxyeicosatetraenoic acid; Ang-II; angiotensin II; AP-1; activator protein 1; ARIC; Atherosclerosis Risk in Communities; ATF-6; activating transcription factor-6; CAC; coronary artery calcification; CARDIA; Coronary Artery Risk Development
Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain
Keywords: Soluble epoxide hydrolase; Escherichia coli; Human embryonic kidney 293 free cells; Recombinant expression; C-terminal domain; EETs; epoxieicosatrienoic acids; AR9281; 1-(1-acetylpiperidin-4-yl)-3-adamantan-1-ylurea; AUDA; 12-[[(tricyclo[3.3.1.13,7]dec-1-
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice
Keywords: Naringenin; Diabetes; Cardiac hypertrophy; PPARs; EETs; CYP2J3; AA; arachidonic acid; ANF; atrial natriuretic factor; BW; body weight; CVF; collagen volume fraction; CYP450; cytochrome P450; DCM; diabetic cardiomyopathy; DHM; diabetic cardiac hypertrophy
Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development
Keywords: PD; Parkinson disease; DA; Dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; HVA; Homovanillic acid; BBB; blood brain barrier; sEH; soluble epoxide hydrolase; mEH; microsomal epoxide hydroxylases; COX-2; cyclooxygenase-2; ROS; reactive oxygen species; AA;
Healthcare-associated ventriculitis and meningitis in a neuro-ICU: Incidence and risk factors selected by machine learning approach
Keywords: CCI; Charlson Comorbidity Index; CDC; the Centers for Disease Control; CI; confidence interval; CSF; cerebrospinal fluid; CSFL-NE; CSF leak from nose and/or ears; CSFL-SS; CSF leak from surgical site (also, if appropriate, from ventricular drain pin-chann
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice
Keywords: BCAS; common carotid artery stenosis; LTP; long-term potentiation; sEH; soluble epoxide hydrolase; NRG1; neuregulin-1; EETs; epoxyeicosatrienoic acids; TPPU; 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea; DHET; dihydroxyeicosatrienoie a
Posttranslational regulation of CYP2J2 by nitric oxide
Keywords: 3-MA; 3-methyladenine; AA; arachidonic acid; ASC; ascorbate; Bort; bortezomib; BST; biotin-switch technique; Calp; calpeptin; CHX; cycloheximide; Dan; danazol; DMEM; Dulbecco's modified Eagle Medium; DPTA; dipropylenetriamine NONOate; EETs; epoxyeicosatri
Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2
Keywords: Cytochrome P450; Inhibitory effects; Danshen; CYP2C8; CYP2J2; Herb-drug interactions; AA; arachidonic acid; CA; caffeic acid; Cry; cryptotanshinone; CYPs; Cytochrome P450 enzymes; DSS; danshensu; DI; dihydrotanshinone I; EETs; epoxyeicosatrienoic acids; F
Quality of Life Changes Following Concurrent Septoplasty and/or Inferior Turbinoplasty During Endoscopic Pituitary Surgery
Keywords: Endoscopic pituitary surgery; Quality of life; Septoplasty; SNOT-22; Turbinoplasty; EETS; Endoscopic endonasal transsphenoidal surgery; NSIG; No septoplasty/inferior turbinoplasty group; QOL; Quality of life; SIG; Septoplasty/inferior turbinoplasty group;
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells
Keywords: Acetylshikonin; CYP2J2; Inhibition; Anti-cancer; HLMs; human liver microsomes; HCC; Hepatocellular carcinoma; DMSO; dimethyl sulfoxide; G6P; glucose-6-phosphate; G6PDH; G6P dehydrogenase; NADP+; β-nicotinamide dinucleotide phosphate; EETs; Epoxyeicosatri
Preoperative Evaluation of the Interface Between Tuberculum Sellae Meningioma and the Optic Nerves on Fast Imaging with Steady-State Acquisition for Extended Endoscopic Endonasal Transsphenoidal Surgery
Keywords: Endoscopic endonasal transsphenoidal surgery; Interface; Magnetic resonance imaging; Optic nerve; Tuberculum sellae meningioma; ACP; Anterior clinoid process; CE; Contrast enhancement; CSF; Cerebrospinal fluid; EETS; Endoscopic endonasal transsphenoidal s
In silico investigation of cycloartane triterpene derivatives from Cimicifuga dahurica (Turcz.) Maxim. roots for the development of potent soluble epoxide hydrolase inhibitors
Keywords: AUDA; 12-(3-adamantan-1-yl-ureido)-dodecanoic acid; COSY; correlated spectroscopy; DHETs; dihydroxyeicosatrienoic acids; EETs; epoxyeicosatrienoic acids; HMBC; heteronuclear multiple bond connectivity; HMQC; heteronuclear multiple quantum coherence; NMR;
11,12 -Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus
Keywords: EETs; Soluble epoxide hydrolase; Neurotransmission; Hippocampus; GIRK channel; Epilepsy;
Potential role of CYP1B1 in the development and treatment of metabolic diseases
Keywords: AA; Arachidonic acid; AHR; aryl hydrocarbon receptor; Ang II; angiotensin II; B[a]P; benzo[a]pyrene; CYP; Cytochrome P450; DB[a,l]P; dibenzo[a,l]pyrene; EETs; epoxyeicosatrienoic acids; ER; estrogen receptor; HETE; hydroxyeicosatetraenoic acids; HFD; high
Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals
Keywords: AA; arachidonic acid; AHH; aryl hydrocarbon hydoxylase; AHR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor translocator; B6; C57BL/6J mice; bHLH; basic-helix/loop/helix domain in proteins; Chr; chromosome; CNS; central nervous system; CYP; cy
Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
Keywords: clinical trial; COPD; EETs; endothelial function; smokers; soluble epoxide hydrolase inhibitor; CYP; cytochrome P450; DHET; dihydroxyepoxyeicosatrienoic acid; EC50; half maximal effective concentration; EDHF; endothelium-derived hyperpolarizing factor; EE
Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population
Keywords: AA; arachidonic acid; CHD; coronary heart disease; CI; confidence intervals; CVD; cardiovascular disorder; EETs; epoxyeicosatrienoic acids; FDR; false discovery rate; HWE; Hardy-Weinberg equilibrium; LRT; log-likelihood ratio test; OR; odds ratio; PCR; po
Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism
Keywords: AUDA; 12-[[(tricyclo[3.3.1.13,7]dec-1ylamino)carbonyl]amino]dodecanoic acid; 4-PBA; 4-phenylbutyric acid; GRP78; 78-kDa glucose-regulated protein; ATF6; Activating transcription factor 6; Ang-II; Angiotensin-II; CYP; Cytochrome P450; ER stress; Endoplasmi
Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase
Keywords: ApoEÂ â/â; Â ApoE deficient; EBM-2; endothelial basal medium-2; EC; endothelial cells; EDN; endothelial human Nox4DN transgenic mice; EETs; epoxyeicosatrienoic acids; eNOS; endothelial nitric oxide synthase; FBS; fetal bovine serum; HAEC; human aortic
Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy
Keywords: AA; arachidonic acid; ATL; inflammatory aspirin-triggered 15-epi-lipoxin A4; COX; cyclooxygenase; CYP; cytochrome P450 enzyme; 5α-DHT; 5α-dihydrotestosterone; DiHETrE; dihydroxyeicosatrienoic acid; EC; endothelial cells; EETs; epoxyeicosatrienoic acid;
Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro
Keywords: Lipid mediator; DNA damage; 32P-postlabelling; EETs; Arachidonic acid; Cytochrome P450;
11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization
Keywords: EETs; Estrogen; Vascular; Endothelial cell; Inflammation; Adhesion; Aging;
Expression of CYP 4A Ï-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes
Keywords: 20-HETE; 20-hydroxyeicosatetraenoic acid; CYP 4A enzyme; cytochrome P450 4A Ï-hydroxylase; EETs; epoxyeicosatrienoic acids; AA; arachidonic acid; HET0016; ((N-hydroxy-Nâ²-(4-butyl-2-methylphenyl)formamidine; CBF; cerebral blood flow; LC-ESI-MS; Liqu
Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase
Keywords: ApoEÂ â/â; Â ApoE deficient; DBP; diastolic blood pressure; EETs; epoxyeicosatrienoic acids; H2O2; hydrogen peroxide; ICAM1; intercellular adhesion molecule 1; LCA; left common carotid artery; MAP; mean arterial pressure; MCP1; monocyte chemoattractan
Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca2+ release
Keywords: AACOCF3; arachidonyl trifluoromethyl ketone; AUDA; 12-(3-adamantan-1-yl-ureido)dodecanoic acid; CP85; Na-1-ethylsulfoxide-2-methyl-3-hyroxypyridin-4-one; CP94; 1,2-diethyl-3-hyroxypyridin-4-one; CPA; Cyclopiazonic Acid; DFO; Desferrioxamine; EC; endotheli
ReviewBeyond neurovascular coupling, role of astrocytes in the regulation of vascular tone
Keywords: AA; arachidonic acid; BBB; blood-brain barrier; CA; cerebral autoregulation; CBF; cerebral blood flow; CO; carbon monoxide; EETs; epoxyeicosatrienoic acids; FH; functional hyperemia; KO; knockout; mGluR; metabotropic glutamate receptor; NO; nitric oxide
Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase
Keywords: EETs; Soluble epoxide hydrolase; Inhibitors; Urea derivatives; Enantioselectivity;
Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern
Keywords: Soluble epoxide hydrolase; Eicosanoids; Oxylipins; Epoxy fatty acids; EETs; Primary rat hepatocytes; Caco-2 intestinal absorption;
Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries
Keywords: LIMAs; human left internal mammary arteries; EETs; epoxyeicosatrienoic acids; 11,12-EET; 11,12-epoxyeicosatrienoic acid; KCa1.1; large conductance Ca2Â +-activated K+ channels; TRPV4; vanilloid transient receptor potential channel 4; TRPC1; canonical tran
Human fetal ventricular cardiomyocyte, RL-14 cell line, is a promising model to study drug metabolizing enzymes and their associated arachidonic acid metabolites
Keywords: RL-14 cells; Cytochrome P450; Epoxyeicosatrienoic acids; EETs; Hydroxyeicosatetraenoic acid; 20-HETE;
Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation
Keywords: AA; arachidonic acid; COX; cyclooxygenases; LOX; lipoxygenases; CYP; cytochrome P450; EETs; epoxyeicosatrienoic acids; HETEs; hydroxyeicosatetraenoic acids; PGs; prostaglandins; PGD2; prostaglandin D2; PTGDS; prostaglandin D2 synthase; TXB2; thromboxane B
CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages
Keywords: CYP2J2; cytochrome P450 2J2 epoxygenase; EET; epoxyeicosatrienoic acids; Iso; isoprenaline; Ang II; angiotensin II; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; TGF-β1; transforming growth factor-beta 1; α-SMA; alpha smooth mu
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
Keywords: 6PGD; 6-phosphogluconate dehydrogenase; 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; ADP; adenosine diphosphate; ADSCs; adipose-derived stem cells; aP2; fatty-acid binding protein; AREs; antioxidant response elements; ATP; adenosine tri
Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease
Keywords: Eicosanoids; Cytochrome P450; Chronic kidney disease; Biomarkers; HETE; EETs; diHETEs
Inhibitory effect of 14,15-EET on endothelial senescence through activation of mTOR complex 2/Akt signaling pathways
Keywords: EETs; epoxyeicosatrienoic acids; eNOS; endothelial nitric oxide synthase; mTOR; mammalian target of rapamycin; mTORC2; mTOR complex 2; RMAECs; rat mesenteric arterial endothelial cells; rTERT; rat telomerase reverse transcriptase; SA-β-gal; senescence-as
Integrated identification/confirmatory and targeted analysis of epoxyeicosatrienosic acids in human serum by LC-TOF MS and automated on-line SPE-LC-QqQ MS/MS
Keywords: ACE; automatic cartridge exchanger; C18 EC; end-capped silica-based octadecyl phase; C18 HD; end-capped silica based phase with a high density of octadecyl chains; C2; silica-based ethyl phase; C8 EC; end-capped silica-based octyl phase; CN; silica-based
Mechanism of the sex difference in neuronal ischemic cell death
Keywords: DMEM; Dulbecco's-Modified Eagle Medium; DMSO; Dimethylsulfoxide; EETs; epoxyeicosatrienoic acids; LC-MS/MS; liquid chromatography-tandem mass spectrometry; MCAO; middle cerebral artery occlusion; PLA2; phospholipase A2; OGD; oxygen-glucose deprivation;