Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro

In summary, when analysed by the 32P-postlabelling method all four racemic EETs formed multiple DNA adducts after activation by acidic pH, only ±11,12-EET produced DNA adducts in aqueous solution at neutral pH. Therefore, we conclude from our in vitro studies that EETs might be endogenous genotoxic compounds.