کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8268302 | 1534954 | 2015 | 87 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
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کلمات کلیدی
Egr2CD36ADPGCLCCAAT/enhancer-binding proteinsAREsAP2Drp1CoQCREBDHODHEETsFis1GCLCGADD153ADSCsGCLMG6PDHeWATETF-QODEXFBSeLOX3COXsCATCHOP-106PGD20-HETEBAT20-Hydroxyeicosatetraenoic acid - 20-Hydroxyeicosatetraenoic اسید6-phosphogluconate dehydrogenase - 6-فسفوگلاوکونات دهیدروژنازC/EBPs - C / EBPC/EBP homologous protein - C / EBP پروتئین همولوگcAMP - cAMPCYPs - CYPAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPadenosine diphosphate - آدنوزین دی فسفاتcytochrome P450 enzymes - آنزیم های سیتوکروم P450Arachidonic acid - اسید آراشیدونیکepoxyeicosatrienoic acids - اسید اپوکسی اسیاتریتروئینepididymal white adipose tissue - بافت چربی سفید اپیدیدیمbrown adipose tissue - بافت چربی قهوه ایβ-catenin - بتا-کاتنینforkhead Box O - جعبه O جعبه ODexamethasone - دگزامتازونdihydroorotate dehydrogenase - دی هیدرووراتا د هیدروژنازelectron transport chain - زنجیره انتقال الکترونfetal bovine serum - سرم جنین گاوAdipose-derived stem cells - سلول های بنیادی حاصل از چربیCyclooxygenases - سیکلوکوکسی ...endoplasmic reticulum - شبکه آندوپلاسمی antioxidant response elements - عناصر پاسخ آنتی اکسیدانFoxO - فاکسوGlutamate–cysteine ligase - لیگاز Glutamate-CysteineETc - و غیرهEarly growth response 2 - پاسخ رشد اولیه 2fatty-acid binding protein - پروتئین متصل به اسید چربDynamin-related protein - پروتئین مربوط به دینامینcAMP response element-binding protein - پروتئین واکنش القا کننده واکنش cAMPCatalase - کاتالازCoenzyme Q - کوآنزیم Qglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity](/preview/png/8268302.png)
چکیده انگلیسی
In view of the global prevalence of obesity and obesity-associated disorders, it is important to clearly understand how adipose tissue forms. Accumulating data from various laboratories implicate that redox status is closely associated with energy metabolism. Thus, biochemical regulation of the redox system may be an attractive alternative for the treatment of obesity-related disorders. In this work, we will review the current data detailing the role of the redox system in adipocyte differentiation, as well as identifying areas for further research. The redox system affects adipogenic differentiation in an extensive way. We propose that there is a complex and interactive “redox chain,” consisting of a “ROS-generating enzyme chain,” “combined antioxidant chain,” and “transcription factor chain,” which contributes to fine-tune the regulation of ROS level and subsequent biological consequences. The roles of the redox system in adipocyte differentiation are paradoxical. The redox system exerts a “tridimensional” mechanism in the regulation of adipocyte differentiation, including transcriptional, epigenetic, and posttranslational modulations. We suggest that redoxomic techniques should be extensively applied to understand the biological effects of redox alterations in a more integrated way. A stable and standardized “redox index” is urgently needed for the evaluation of the general redox status. Therefore, more effort should be made to establish and maintain a general redox balance rather than to conduct simple prooxidant or antioxidant interventions, which have comprehensive implications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 89, December 2015, Pages 99-125
Journal: Free Radical Biology and Medicine - Volume 89, December 2015, Pages 99-125
نویسندگان
Xin Wang, Chunxu Hai,