Keywords: آنزیم های سیتوکروم P450; Comet assay; DNA repair capability; Metabolites; Photosensitized DNA damage; Phototoxicity; DCF; diclofenac; 5OH-DCF; 5-hydroxy-diclofenac; 4â²OH-DCF; 4â²-hydroxy-diclofenac; CPZ; chlorpromazine; SDS; sodium dodecyl sulphate; NSAID; nonsteroidal antiinf
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Keywords: آنزیم های سیتوکروم P450; 15-PGDH; 15-hydoxyprostaglandin dehydrogenase; AA; arachidonic acid; AF; atrial fibrillation; AKI; acute kidney injury; Akt; alpha serine/threonine-protein kinase; ALA; alpha-linolenic acid; AMD; age-related macular degeneration; Ang II; angiotensin II; B
Keywords: آنزیم های سیتوکروم P450; 4-ABP; 4-aminobiphenyl; CI; confidence interval; CrI; credible interval; AA-Hb; acrylamide-hemoglobin; AcE; acetylcholinesterase; AhR; aryl hydrocarbon receptor; APFO; ammonium perfluorooctanoate; AR; androgen receptor; BBMP; 2,2-bis(bromomethyl)-1,3-prop
Keywords: آنزیم های سیتوکروم P450; BTZ; bortezomib; CFZ; carfilzomib; C-L; caspase-like; CNS; central nervous system; CT-L; chymotrypsin-like; CYPs; cytochrome P450 enzymes; iP; immunoproteasome; IXZ; ixazomib; MM; multiple myeloma; OPZ; oprozomib; PD; pharmacodynamic; PI; proteasome inhib
Keywords: آنزیم های سیتوکروم P450; Dopamine; Ecstasy; Methamphetamine; METH; 3,4-Methylenedioxymethamphetamine; MDMA; Mouse; Neurodegeneration; Neuroinflammation neurotoxicity; Non-human primate; Rat; AC; adenylyl cyclase; AcbSh; nucleus accumbens shell; AcbC; nucleus accumbens core; cAMP;
Keywords: آنزیم های سیتوکروم P450; PCBs; polychlorinated biphenyls; IARC; International Agency for Research on Cancer; TCDD; 2,3,7,8-tetrachlorodibenzopara-dioxin; MFOs; mixed function oxidases; CYP; cytochrome P450 enzymes; RR; risk ratio; OR; odds ratio; SE; standard errors; CI; confiden
Keywords: آنزیم های سیتوکروم P450; Nasal epithelium; Aryl hydrocarbon receptor (AhR); Cytochrome P450 enzymes; Estrogen receptor; Hydrocarbon polycyclic aromatic; PAHs; polycyclic aromatic hydrocarbons; RT-PCR; real time-polymerase chain reaction; PM; particulate matter; PM2.5; particulate
Keywords: آنزیم های سیتوکروم P450; Cytochrome P450 enzymes; Microsomal epoxide hydrolase; Microsomal glutathione-S-transferases; Microsomes; Nano liquid chromatography–tandem multiple reaction monitoring
Keywords: آنزیم های سیتوکروم P450; 5FU; 5-fluorouracile; ABC; ATP-binding cassette; AUC; area under the curve; BCRP; breast cancer resistance protein; Cmax; maximum (peak) plasma concentration; CYP; cytochrome p450 enzymes; DDI; drug-drug interactions; EIAEDS; enzyme-inducing antiepilept
Keywords: آنزیم های سیتوکروم P450; ABC; ATP-binding cassette; ADH; alcohol dehydrogenase; ADR; adrenodoxin reductase; ADX; adrenodoxin; ARE2; sterol acyltransferase; ARV1; mediator of sterol homeostasis; BTS1; GGPP synthase; CPR; cytochrome P450 reductase; CRT; carotenogenic (genes); CYP;
LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity
Keywords: آنزیم های سیتوکروم P450; 1-OH-MDZ; 1-hydroxymidazolam; 4-OH-DCL; 4-hydroxydiclofenac; 5-OH-OME; 5-hydroxyomeprazole; CYP; cytochrome P450 enzymes; DXP; dextrorphan; ESI; electrospray ionization; EZE-Glc; ezetimibe glucuronide; LC-MS/MS; liquid chromatography tandem mass spectro
The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins
Keywords: آنزیم های سیتوکروم P450; Berberine; Statins; Cytochrome P450 enzymes; hERG potassium channel; Cardiotoxicity;
Relationship between the hippocampal expression of selected cytochrome P450 isoforms and the animal performance in the hippocampus-dependent learning task
Keywords: آنزیم های سیتوکروم P450; Cytochrome P450 enzymes; Hippocampus; Rats; Spatial learning and memory;
Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis
Keywords: آنزیم های سیتوکروم P450; CE; capillary electrophoresis; Clint; intrinsic clearance; CLM; canine liver microsomes; CYP; cytochrome P450 enzymes; D; diazepam; DHNK; 5,6-dehydronorketamine; ELM; equine liver microsomes; HLM; human liver microsomes; HNK; hydroxynorketamine; IST; inte
Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2
Keywords: آنزیم های سیتوکروم P450; Cytochrome P450; Inhibitory effects; Danshen; CYP2C8; CYP2J2; Herb-drug interactions; AA; arachidonic acid; CA; caffeic acid; Cry; cryptotanshinone; CYPs; Cytochrome P450 enzymes; DSS; danshensu; DI; dihydrotanshinone I; EETs; epoxyeicosatrienoic acids; F
In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes
Keywords: آنزیم های سیتوکروم P450; Ahr; aryl hydrocarbon receptor; Car; constitutive androstane receptor; Pxr; pregnane X receptor; mPEG2k-PCLx micelles; Cytochrome P450 enzymes; Inhibition; Induction; Rat liver microsomes; Primary rat hepatocytes;
In vitro and in vivo cytochrome P450 3A enzyme inhibition by Aframomum melegueta and Denniettia tripetala extracts
Keywords: آنزیم های سیتوکروم P450; Cytochrome P450 enzymes; CYP 3A; Enzyme inhibition; Herbal extracts;
Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver
Keywords: آنزیم های سیتوکروم P450; Chloramine-T; Cytochrome P450 enzymes; Peroxisomal enzymes; Rat liver;
The self-sufficient CYP102 family enzyme, Krac9955, from Ktedonobacter racemifer DSM44963 acts as an alkyl- and alkyloxy-benzoic acid hydroxylase
Keywords: آنزیم های سیتوکروم P450; Cytochrome P450 enzymes; Monooxygenases; Fatty acid oxidation; Ktedonobacter; Alkylbenzoic acids; Alkyloxybenzoic acids; BSTFA; N,O-Bis(trimethylsilyl)trifluoroacetamide; CYP; cytochrome P450 enzyme; DEAE; diethylaminoethanol; DMSO; dimethyl sulfoxide; EM
Effects of diosmetin on nine cytochrome P450 isoforms, UGTs and three drug transporters in vitro
Keywords: آنزیم های سیتوکروم P450; Diosmetin; Cytochrome P450; UDP-glucuronyltransferases; Hepatic uptake transporters; Drug-drug interactions; CYPs; Cytochrome P450 enzymes; DDI; drug-drug interactions; HDI; herb-drug interactions; HLMs; human liver microsomes; NTCP; Na+-taurocholate cotr
Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence
Keywords: آنزیم های سیتوکروم P450; Breast cancer; Cytochrome p450 enzymes; Polymorphism; Grilled and smoked meat; Gene-environment interactions;
In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids
Keywords: آنزیم های سیتوکروم P450; CYP; cytochrome P450; P450s; cytochrome P450 enzymes; RLM; rat liver microsomes; CYP3A4; Resveratrol; Nitrostilbene; Di-methoxy-nitrostilbene; Microsomes; Docking;
Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers
Keywords: آنزیم های سیتوکروم P450; Triadimefon; Eremias argus; Sex steroid hormones; 17-beta-hydroxysteroid; Steroid hormone receptors; Cytochrome P450 enzymes;
Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo
Keywords: آنزیم های سیتوکروم P450; MMI; methimazole; P450s; cytochrome P450 enzymes; FMOs; flavin-containing monooxygenases; Dmfmos; Drosophila melanogaster flavin-containg monooxygenase 1 and 2; s6k; ribosomal protein S6 kinase; fas; fatty acid synthase; acc; acetyl-CoA carboxylase; cpt;
Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE)
Keywords: آنزیم های سیتوکروم P450; AEA; arachidonoyl ethanolamide; AG; arachidonoyl glycerol; ALA; alpha-linolenic acid; ARA; arachidonic acid; BHT; butylated hydroxytoluene; BMI; body mass index; COX; cyclooxygenase; CYP; cytochrome P450 enzymes; DGLA; dihomo-gamma-linolenic acid; DHA; do
Testosterone metabolism of equine single CYPs of the 3A subfamily compared to the human CYP3A4
Keywords: آنزیم های سیتوکروم P450; POR; NADPH P450 oxidoreductase; CYPs; cytochrome P450 enzymes; CYB5; cytochrome b5; Sf9; insect cells of Spodoptera frugiperda; HPLC; high-pressure liquid chromatography; NADPH; nicotinamide adenine dinucleotide phosphate; NDSB; non-detergent sulfobetaine
Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx.
Keywords: آنزیم های سیتوکروم P450; AC; Aconitine; BAC; 14-Benzoylaconine or 8-O-deacetyl aconitine; BHA; 14-Benzoylhypaconine or 8-O-deacetyl hypaconitine; BMA; 14-Benzoylmesaconine or 8-O-deacetyl mesaconitine; CHAPS; 3-[(3-cholamidopropyl) dimethyl-ammonio]-1-propane sulfonate; CYP450s;
The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of α-naphthoflavone
Keywords: آنزیم های سیتوکروم P450; PAH(s); polycyclic aromatic hydrocarbon(s); ARNT; aryl hydrocarbon nuclear translocator; αNF; α-naphthoflavone; BaP; benzo[a]pyrene; DMBA; dimethylbenz[a]anthracene; 3MC; 3-methylcholanthrene; AhR; aryl hydrocarbon receptor; Po; primordial follicle; Pi;
Characterisation of two self-sufficient CYP102 family monooxygenases from Ktedonobacter racemifer DSM44963 which have new fatty acid alcohol product profiles
Keywords: آنزیم های سیتوکروم P450; BSTFA; N,O-bis(trimethylsilyl)trifluoroacetamide; CYP; cytochrome P450 enzyme; DEAE; diethylaminoethanol; DMSO; dimethyl sulfoxide; EMM; Escherichia coli minimal media; EtOH; ethanol; GC; gas chromatography; HPLC; high performance liquid chromatography; I
Fipronil induces CYP isoforms in rats
Keywords: آنزیم های سیتوکروم P450; Fipronil; Cytochrome P450 enzymes; Hepatic microsomes; Rats;
Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2
Keywords: آنزیم های سیتوکروم P450; MBI; mechanism-based inhibition; RMs; reactive metabolites; CYPs; cytochrome P450 enzymes; GSH; reduced glutathione; HLMs; human liver microsomes; NADPH; β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt; MI complex; metabolite
Novel binuclear μ-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential
Keywords: آنزیم های سیتوکروم P450; Binuclear ruthenium compounds; Ibuprofen; Ketoprofen; IgE-mediated allergic diseases; Antiallergic potential; Cytochrome P450 enzymes;
Subacute nicotine co-exposure has no effect on 2,2â²,3,5â²,6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat
Keywords: آنزیم های سیتوکروم P450; Ct; fractional amplification (cycle number at which fluorescence exceeds a user-defined threshold); d; day; b.w.; body weight; DE; diatomaceous earth; EF; enantiomeric fraction; qPCR; quantitative (real-time) polymerase chain reaction; PCBs; polychlorinat
Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane
Keywords: آنزیم های سیتوکروم P450; Estrogen receptor-positive breast cancer; Aromatase inhibitors; Exemestane metabolites; Apoptosis; Autophagy; Acquired-resistance; AIs; aromatase inhibitors; AO; acridine orange; AVOs; acid vesicular organelles; CCCP; carbonyl cyanide m-chlorophenylhydraz
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
Keywords: آنزیم های سیتوکروم P450; 6PGD; 6-phosphogluconate dehydrogenase; 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; ADP; adenosine diphosphate; ADSCs; adipose-derived stem cells; aP2; fatty-acid binding protein; AREs; antioxidant response elements; ATP; adenosine tri
Pulmonary administration of Am80 regenerates collapsed alveoli
Keywords: آنزیم های سیتوکروم P450; COPD; chronic obstructive pulmonary disease; Am80; 4[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid; ATRA; all-trans-retinoic acid; CYP; cytochrome P450 enzymes; CRABP; cellular retinoic acid binding protein; RAR; nuclear re
Frequency distribution of high risk alleles of CYP2C19, CYP2E1, CYP3A4 genes in Haryana population
Keywords: آنزیم های سیتوکروم P450; Xenobiotic metabolizing genes; Genetic polymorphism; Haryana population; Cytochrome P450 enzymes;
The crab Carcinus maenas as a suitable experimental model in ecotoxicology
Keywords: آنزیم های سیتوکروم P450; 6PGDH; 6-phosphogluconate dehydrogenase; AChE; acetylcholinesterase; AWP; apparent water permeability; BChE; butyrylcholinesterase; BP; benzopyrene; BPH; benzopyrene hydroxylase; BPMO; benzopyrene monoxygenase; BRI; Biomarker Response Index; CAT; catalase
Effect of natamycin on cytochrome P450 enzymes in rats
Keywords: آنزیم های سیتوکروم P450; Natamycin; Cytochrome P450 enzymes; Hepatic microsomes; Rats;
Induction of cytochrome P450 enzymes in primary equine hepatocyte culture
Keywords: آنزیم های سیتوکروم P450; FBS; fetal bovine serum; CYPs; cytochrome P450 enzymes; HBSS; Hanks' balanced salt solution; HTK; histidine-tryptophan-ketoglutarate; WEM; Williams' medium E; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl-sulphoxide; EGTA; ethylene glycol t
Research ArticleMouse KLF11 regulates hepatic lipid metabolism
Keywords: آنزیم های سیتوکروم P450; ALT; alanine aminotransferase; AST; aspartate aminotransaminase; Col1α1; collagen type 1α1; CPT1a; carnitine palmitoyl transferase 1a; CTGF; connective tissue growth factor; CYP4A10 and CYP4A14; cytochrome P450 enzymes; DIO; diet-induced obese; FAS; fat
Accelerated degradation of retinoic acid by activated microglia
Keywords: آنزیم های سیتوکروم P450; Microglia; LPS; Cytochrome P450 enzymes; Neuroinflammation; Retinoic acid
Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?
Keywords: آنزیم های سیتوکروم P450; Cytochrome P450 enzymes; CYP27A1; CYP2R1; CYP2J2/3; CYP3A4; CYP2D25; CYP2C11
Modulatory effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes
Keywords: آنزیم های سیتوکروم P450; Kaempferia parviflora; Cytochrome P450 enzymes; Drug-herb interaction; Induction; Inhibition; Enzyme activity;
Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen
Keywords: آنزیم های سیتوکروم P450; P450; cytochrome P450 enzymes; 4OHT; 4-hydroxy-tamoxifen; SOM; sites of metabolism; RALX; raloxifene; P450; 4-Hydroxyâtamoxifen; Dehydrogenation; Molecular dynamics; Docking; Conformational dynamics;
Comparative efficacy and bioavailability of different praziquantel brands
Keywords: آنزیم های سیتوکروم P450; Praziquantel; Schistosoma mansoni; Cytochrome P450 enzymes; Bioavailability; Drug metabolism; Physicochemical properties;
Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation
Keywords: آنزیم های سیتوکروم P450; ACN; acetonitrile; APAP; acetaminophen; CYP1A2; cytochrome P450 1A2 enzyme; CYP2B6; cytochrome P450 2B6 enzyme; CYP2C19; cytochrome P450 2C19 enzyme; CYP2D6; cytochrome P450 2D6 enzyme; CYP3A4; cytochrome P450 3A4 enzyme; CYP450; cytochrome P450 enzymes;
The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver
Keywords: آنزیم های سیتوکروم P450; Circadian clock; PAS genes; Xenobiotics; Aryl hydrocarbon receptor; AhR nuclear translocator; Cytochrome p450 enzymes
Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver
Keywords: آنزیم های سیتوکروم P450; Clock genes; Period1; Period2; PAS genes; Circadian rhythms; Hepa1c1c7; Xenobiotics; Polycyclic aromatic hydrocarbons; Aryl hydrocarbon receptor; AhR nuclear translocator; Cytochrome p450 enzymes; siRNA
Drug metabolism
Keywords: آنزیم های سیتوکروم P450; bioactivation; cytochrome P450 enzymes; enzyme induction; enzyme inhibition; genetic polymorphisms; interactions; metabolism