کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2595455 | 1562311 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of α-naphthoflavone
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CyPBAPDMBADimethylbenz[a]anthraceneαNF3-methylcholanthreneARNT3MCAHRα-Naphthoflavone - α-نفتوفلوانcytochrome P450 enzymes - آنزیم های سیتوکروم P450aryl hydrocarbon nuclear translocator - اتمسفر هسته ای آرویل هیدروکربنVaginal opening - باز شدن واژنBenzo[a]pyrene - بنزو [a] پییرنovulation - تخمک گذاریFollicular growth - رشد فولیکولیAntral follicle - فولیکول آنترالPrimordial follicle - فولیکول اولیهPrimary follicle - فولیکول اولیهPreantral follicle - فولیکول پیش قلبیMicronucleus - میکروسکوپpolycyclic aromatic hydrocarbon(s) - هیدروکربن های آروماتیک چند حلقه)aryl hydrocarbon receptor - گیرنده آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, we investigated the effect of 3-methylcholanthrene (3MC) on sexual maturity and the ability of α-naphthoflavone (αNF) to prevent this action. To this end, immature rats were daily injected intraperitoneally with 3MC (0.1 or 1 mg/kg) and/or αNF (80 mg/kg). Body weight, vaginal opening and estrous cycle were recorded and ovaries were obtained on the day of estrus. Ovarian weight, ovulation rate (measured by the number of oocytes within oviducts), and follicular development (determined by histology) were studied. No differences were found in body weight, ovarian weight, day of vaginal opening, or the establishment of the estrous cycle among the different groups of rats. However, animals treated with 3MC, at both doses, exhibited a lower number of primordial, primary, preantral and antral follicles than controls. Also, 3MC inhibited the ovulation rate and induced an overexpression of both the Cyp1a1 and Cyp1b1 genes, measured by chromatin immunoprecipitation assay. The daily treatment with αNF alone increased the number of follicles in most of the stages analyzed when compared with controls. Moreover, the αNF treatment prevented completely not only the 3MC-induced decrease in all types of follicles but also the 3MC-induced overexpression of Cyp enzymes and the genetic damage in bone marrow cells and oocytes. These results suggest that (i) daily exposure to 3MC during the pubertal period destroys the follicle reserve and alters the ovulation rate; (ii) the 3MC action seems to be mediated by an aryl hydrocarbon receptor-dependent mechanism; (iii) daily administration of αNF has a clear stimulatory action on the ovarian function; and (iv) αNF may prevent both the systemic and gonadal 3MC-induced toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volumes 353â354, 15 April 2016, Pages 58-69
Journal: Toxicology - Volumes 353â354, 15 April 2016, Pages 58-69
نویسندگان
Eric Alejandro Rhon-Calderón, RocÃo Alejandra Galarza, Alejandro Lomniczi, Alicia Graciela Faletti,