Keywords: 20-MC; 20-Methylcholanthrene; 3-MC; 3-Methylcholanthrene; ALDH; aldehyde dehydrogenase A1; AsA; ascorbate; APx; ascosbate peroxidase; As2O3; arsenic trioxide; BSO; L-buthionine-(S,R)-sulfoximine; CNS; Central Nervous System; DMBA; 7,12-Dimethylbenz[a]anth
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Keywords: 3-MC; 3-methylcholanthrene; Ah; aryl hydrocarbon; AhE; aryl hydrocarbon receptor; AP-1; activator protein-1; ARE; antioxidant response element; ATF4; activating transcription factor 4; β-NF; β-naphthoflavone; β-NF-RE; β-NF-responsive element; β-TRCP;
Keywords: ACC; Accuracy; AUC; Area Under the Curve; CTA; in vitro cell transformation assay; DMSO; Dimethylsulfoxide; ED; Equivalent Diameter; EFP; perimeter of the circle with equivalent area; FN; false negative; FP; false positive; FRP; perimeter of the region co
Keywords: 1-Mnap; 1-methyl naphthalene; 2-Mnap; 2-methyl naphthalene; 3-MChl; 3-methylcholanthrene; Acne; acenaphthene; AcNy; acenapthylene; AlM; aluminium thermal metallurgy; An; anthracene; BaA; benzo(a)anthracene; BaP; benzo(a)pyrene; BbF; benzo(b)fluoranthene;
Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction
Keywords: cytochrome P450; mathematical models; hepatocytes; drug-drug interaction; induction; CAR; constitutive androstane receptor; CITIO; 6-(4-clorophenyl) imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; P450; cytochrome P450; DDI; drug-d
p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism
Keywords: AHR; aryl hydrocarbon receptor; ARNT; AHR nuclear translocator; p23; p23 co-chaperone; Hsp90; heat shock protein 90; XAP2; hepatitis virus B X-associated protein 2; 3-MC; 3-methylcholanthrene; βNF; β-napthoflavone, DRE, dioxin response element; GST; glu
Review articleReview on crosstalk and common mechanisms of endocrine disruptors: Scaffolding to improve PBPK/PD model of EDC mixture
Keywords: 3MC; 3-methylcholanthrene; 5α-R; 5-alpha reductase; ACTH; adrenocorticotropic hormone; Ahr; aryl hydrocarbon receptor; Ahrr; aryl hydrocarbon receptor repressor; AKT; serine/threonine kinase; AMH; anti-mullerian hormone; AMPO; ammonium perfluorooctane; A
One electron oxidation of 3-methylcholanthrene: A chemical model for its mechanism of carcinogenesis
Keywords: 3-Methylcholanthrene; Polycyclic aromatic hydrocarbons; One-electron oxidation; Carcinogenesis; Metabolic activation;
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
Keywords: FLU; flutamide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC; 3-methylcholanthrene; ABCC4; ATP-binding cassette sub-family C member 4; MRP4; mul
The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of α-naphthoflavone
Keywords: PAH(s); polycyclic aromatic hydrocarbon(s); ARNT; aryl hydrocarbon nuclear translocator; αNF; α-naphthoflavone; BaP; benzo[a]pyrene; DMBA; dimethylbenz[a]anthracene; 3MC; 3-methylcholanthrene; AhR; aryl hydrocarbon receptor; Po; primordial follicle; Pi;
Distribution and excretion of 2,2â²,3,4â²,5,5â²,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs
Keywords: PCB; polychlorinated biphenyls; OH; hydroxy; GC; gas chromatography; ECD; electron capture detector; MS; mass spectrometry; PB; phenobarbital; MC; 3-methylcholanthrene; IP; intraperitoneally; heptaCB; heptachlorobiphenyl; hexaCB; hexachlorobiphenyl; penta
Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions
Keywords: AHR; aryl hydrocarbon receptor; Ahr2; aryl hydrocarbon receptor 2; APC; adenomatosis polyposis coli; AZP; 1-azakenpaullone; CKIα; casein kinase Iα; CYP1; cytochrome P450 1; DLCs; dioxin-like compounds; DMSO; dimethyl sulfoxide; dpf; days post-fertilizat
Expression of microRNAs, CYP1A1 and CYP2B1 in the livers and ovaries of female rats treated with DDT and PAHs
Keywords: DDT (PubChem CID: 3036); Benzo[a]pyrene (PubChem CID: 611); 3-Methylcholanthrene (PubChem CID: 1674)miRNA; DDT; PAH; Benzo[a]pyrene; 3-Methylcholanthrene; Rat; CYP1A1; CYP2B1; Expression level
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR
Keywords: AhR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BaPD; (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene; BaPDE; (±)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; BcP; benzo[c]phenanthrene; BcPD; (±)-trans-3,4-dihydroxy-3,4-dihyd
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A
Keywords: 3-MC; 3-methylcholanthrene; AHR; aryl hydrocarbon receptor; bHLH/PAS; basic helix-loop-helix/Per-Arnt-Sim; ChIP; chromatin immunoprecipitation; Dex; dexamethasone; GR; glucocorticoid receptor; GRE; glucocorticoid response element; MT; metallothion
The emerging roles of AhR in physiology and immunity
Keywords: 3MC; 3-methylcholanthrene; AhR; aryl hydrocarbon receptor; AhRR; AhR repressor; AIP; AhR interacting protein; APC; antigen presenting cell; Arnt; aryl hydrocarbon receptor nuclear translocator; bHLH/PAS; basic helix-loop-helix/Per-Arnt-Sim; β-NF; beta-na
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane
Keywords: I3C; indole-3-carbinol; SFN; sulforaphane; DBC; dibenzo[def,p]chrysene; GFN; glucoraphanin; GSH; glutathione; CG; cysteine-glycine; Cys; cysteine; NAC; N-acetylcysteine; 3-MC; 3-methylcholanthrene; DMBA; 7,12-dimethylbenz[a]anthracene; BaP; benzo[a]pyre
The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polκ), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver
Keywords: AhR; aryl hydrocarbon receptor; ARNT; AhR nuclear translocator; Polκ; polymerase (DNA directed) kappa; PolR2a; RNA polymerase II (DNA directed) polypeptide A; CYP1A1; cytochrome P450 1A1; CYP1B1; cytochrome P450 1B1; BNF; β-naphthoflavone; 3-MC; 3-methy
Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon nuclear translocator; αNF; α-naphthoflavone; eCG; equine chorionic gonadotrophin; hCG; human chorionic gonadotrophin; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; DMBA; dimethylbenz[a]anthracene; BaP;
Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis
Keywords: CIS; carcinoma in situ; DEN; diethylnitrosamine; MCA; 3-methylcholanthrene; MSP; methylation-specific polymerase chain reaction; DNA repair; DNA methylation; Carcinogenesis; Lung cancer;
Precision-Cut Liver Slices of Salmo salar as a tool to investigate the oxidative impact of CYP1A-mediated PCB 126 and 3-methylcholanthrene metabolism
Keywords: Precision-Cut Liver Slices; CYP1A induction; Oxidative stress; Antioxidant enzymes; 3-Methylcholanthrene; PCB 126
Prenatal administration of the cytochrome P4501A inducer, Î-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants
Keywords: BPD; bronchopulmonary dysplasia; CYP; cytochrome P450; BNF; Ã-napthoflavone; CO; corn oil; EROD; ethoxyresorufin O-deethylase; MROD; methoxyresorufin O-demethylase; ROS; reactive oxygen species; MC; 3-methylcholanthrene; AHR; Ah receptor; RT-PCR; reverse
Cross-species comparison of fluoxetine metabolism with fish liver microsomes
Keywords: Fish; Fluoxetine; Cytochrome P450; Norfluoxetine; Carbamazepine; 3-Methylcholanthrene
AhR and ARNT modulate ER signaling
Keywords: Estrogen receptors; ARNT; Endocrine disruption; 2,3,7,8-Tetrachlorodibenzo-p-dioxin; 3-Methylcholanthrene; Metabolism
Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport
Keywords: Fatty acid translocase; Aryl hydrocarbon receptor; Peroxisome proliferator-activated receptor α; Monounsaturated fatty acid; 3-Methylcholanthrene; Nonalcoholic fatty liver disease
TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes
Keywords: VEGF; vascular endothelial growth factor; VEGFR; vascular endothelial growth factor receptor; TSU-16; (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; CYP; cytochrome P450; AhR; aryl hydrocarbon receptor; OMP; omeprazole; 3MC; 3-methylcholanthr
Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(−/−) mice
Keywords: Cytochrome P450; Aroclor 1254; Mono-oxygenase activity; Cyp1a2(−/−); 3-Methylcholanthrene
Gene cloning of a sigma class glutathione S-transferase from abalone (Haliotis diversicolor) and expression analysis upon bacterial challenge
Keywords: 3-MC; 3-methylcholanthrene; abGSTsigma; H. diversicolor sigma class GST; CD; conserved domain; CDD; Conserved Domain Database; CDNB; 1-chloro-2,4-dinitrobenzene; GST; glutathione S-transferases; G-sites; GSH-binding sites; GlSTrs; partial cDNA of GST; HLS
Glucocorticoid and adrenalectomy effects on the rat aryl hydrocarbon receptor pathway depend on the dosing regimen and post-surgical time
Keywords: Aryl hydrocarbon receptor; Adrenalectomy; Aryl hydrocarbon receptor nuclear translocator; Glucocorticoids; 3-Methylcholanthrene; Cytochrome P450 1B1
Effect of naturally occurring phenolic acids on the expression of glutathione S-transferase isozymes in the rat
Keywords: GST, glutathione S-transferase; MC, 3-methylcholanthrene; PCA, protocatechuic acid; TA, tannic acidProtocatechuic acid; Tannic acid; 3-Methylcholanthrene; GST isozymes; Rats liver and kidney
Cytochrome P450 2C11 5â²-flanking region and promoter: Regulation by aromatic hydrocarbons in vitro
Keywords: Aryl hydrocarbon receptor; CYP2C11; 2,3,7,8-Tetrachlorodibenzo-p-dioxin; 3-Methylcholanthrene; Dioxin-responsive element; HepG2 cells;
Age-dependent in situ hepatic and gill CYP1A activity in the see-through medaka (Oryzias latipes)
Keywords: Chemical sensitivity; Cytochrome P450; CYP1A; EROD; Ethoxyresorufin; Fish toxicology; Internal organ; Larval toxicology; 3-methylcholanthrene; See-through medaka
3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells
Keywords: 3-Methylcholanthrene; CYP1A1; Gene regulation; 32P-Postlabeling; Ah receptor; DNA adducts; Sequence-specific; Transient transfections;
Identification of amino acid residues in the Ah receptor involved in ligand binding
Keywords: AhR; aryl hydrocarbon receptor; MC; 3-methylcholanthrene; β-NF; β-naphthoflavone; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; YFP; yellow fluorescent protein; Ah receptor; Computer modeling; Ligand binding; PAS domain; Xenobiotics;
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells
Keywords: AhR; aryl hydrocarbon receptor; BNF; beta-naphtoflavon; DMSO; dimethylsulfoxide; EROD; 7-ethoxyresorufine-O-deethylase; FCS; foetal calf serum; CHE; chelerythrine; HepG2; human hepatoma cells; 3-MC; 3-methylcholanthrene; NF-κB; nuclear factor kappa beta;
Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells
Keywords: Aryl-hydrocarbon receptor; 3-Methylcholanthrene; Dioxin; Polycyclic aromatic hydrocarbons; Angiogenesis
The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1α, CYP1A1 and NQO1 genes in rat liver
Keywords: AhR; ARNT; CYP1A1; β-Naphthoflavone; 3-Methylcholanthrene; 2,3,7,8-Tetrachlorodibenzo-p-dioxinAhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator (synonym HIF1β); AhRR, AhR repressor; HIF1α, hypoxia inducible factor 1α; CYP1A1, cytochrome P450
Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene
Keywords: Ah receptor; 3-methylcholanthrene; Estrogen receptor; AhR-ER cross-talk;
Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins
Keywords: AhR; aryl hydrocarbon receptor; Arnt; AhR nuclear translocator; bHLH; basic helix-loop-helix; CYP; cytochrome P450; DMSO; dimethylsulfoxide; DRE; dioxin response element; DTT; dithiothreitol; ELISA; enzyme-linked immunosorbent assay; EROD; ethoxyresol
The role of aryl hydrocarbon receptor and the reactive oxygen species in the modulation of glutathione transferase by heavy metals in murine hepatoma cell lines
Keywords: AhR; aryl hydrocarbon receptor; ARE; antioxidant responsive elements; ARNT; AhR nuclear translocator; C12; AhR-deficient murine hepatoma Hepa 1c1c7 cells; BaP; benzo[a]pyrene; Cu2+; copper; DCF-DA; 2â²,7â²-dichlorofluorescein diacetate; GST; glutathione
Environmental prognostics: An integrated model supporting lysosomal stress responses as predictive biomarkers of animal health status
Keywords: Autophagy; Environmental risk; Eukaryotes; Health status; Lipofuscin; Lysosomes; 3-methylcholanthrene; Mussels; Oxyradicals; PAHs; Pollutants; Prognostic biomarkers; Simulation modelling
Transcription factor NF2d9 (LBP-1a) interacts with the positive regulatory element for the xenobiotic responsive element
Keywords: 3-MC; 3-methylcholanthrene; AhR; arylhydrocarbon receptor; Arnt; AhR nuclear translocator; PREX; positive regulatory element for XRE-mediated gene expression; XRE; xenobiotic responsive element; Arylhydrocarbon receptor; CYP2A8; NF2d9; PREX; Xenobiotic re
PPARα activation potentiates AhR-induced CYP1A1 expression
Keywords: Human CYP1A1; 3-Methylcholanthrene; WY14643; AhR; PPARα; Induction;
Interleukin-1α and tumor necrosis factor α modulate cytochrome P450 activities in carp (Cyprinus carpio)
Keywords: Cytokines; Modulation; Cytochrome P4501A; Carp; Ah-R; Aryl hydrocarbon receptor; alpha-NF; α-naphtoflavone; BaP; Benzo[a]pyrene; Cyp 1A; Cytochrome P450 1A; DMBA; 7; 12-dimethylbenz[a]anthracene; DTT; dithiothreitol; EROD; 7-ethoxyresorufin-O-deethylase;
Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene
Keywords: AHH; aryl hydrocarbon hydroxylase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; MC; 3-methylcholanthrene; PAH; polycyclic aromatic hydrocarbon; RAL; relative adduct labeling; Pas; pulmonary adenoma susceptibility; RT-PCR; reverse transcription polymer
Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines
Keywords: Nickel oxide; Nickel monosulfide; 3-Methylcholanthrene; Ect2 Gene; Gene amplification; mRNA differential display; Reverse transcription; Polymerase chain reaction;
Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells
Keywords: ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; BP; benzo[a]pyrene; 3-OH-BP; 3-hydroxybenzo[a]pyrene; INF; indeno[1,2,3-cd]fluoranthene; 3-MC; 3-methylcholanthrene; β-NF; β-naphthoflavone; CYP; cytochrome P450; DMSO; dimethylsulfoxide; GST; g
Molecular mechanism of the aryl hydrocarbon receptor activation by the fungicide iprodione in rainbow trout (Oncorhynchus mykiss) hepatocytes
Keywords: Cytochrome P4501s; Aryl hydrocarbon receptor; Rainbow trout hepatocytes; Reporter gene assay; Luciferase; Iprodione; 3-Methylcholanthrene;
Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction
Keywords: Primary hepatocytes; Alginate beads; In vitro systems; Enzyme induction; Phenobarbital; 3-Methylcholanthrene; Testosterone hydroxylation;