کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10799375 1054324 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcription factor NF2d9 (LBP-1a) interacts with the positive regulatory element for the xenobiotic responsive element
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Transcription factor NF2d9 (LBP-1a) interacts with the positive regulatory element for the xenobiotic responsive element
چکیده انگلیسی
PREX is a positive regulatory element for xenobiotic responsive element (XRE)-mediated gene expression that is located upstream of the XRE in the CYP2A8 gene. Using gel mobility shift assays, we demonstrated that NF2d9 (LBP-1a), a transcription factor related to CP2 (LBP-1c/LSF), bound directly to PREX and also interacts indirectly with XRE. Luciferase-reporter gene assays showed that the overexpression of NF2d9 enhanced PREX and XRE-driven CYP2A8 gene transcriptional induction. These findings suggest that the interaction of NF2d9 with PREX and XRE enhances XRE-driven CYP2A8 gene transcriptional induction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression - Volume 1727, Issue 2, 14 February 2005, Pages 141-144
نویسندگان
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