Keywords: FBS; fetal bovine serum; EROD; ethoxyresorufin-O-deethylase; AhR; aryl hydrocarbon receptor; XRE; xenobiotic response element; DMBA; 7, 12-dimethylbenz[α] anthracene; PAH; polycylic aromatic hydrocarbon; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; Citrus;
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Keywords: 11βHSD; 11β-Hydroxysteroid dehydrogenase; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; BCRP; breast cancer resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P45
Keywords: 3-MC; 3-methylcholanthrene; Ah; aryl hydrocarbon; AhE; aryl hydrocarbon receptor; AP-1; activator protein-1; ARE; antioxidant response element; ATF4; activating transcription factor 4; β-NF; β-naphthoflavone; β-NF-RE; β-NF-responsive element; β-TRCP;
Keywords: AhR; aryl hydrocarbon receptor; XRE; xenobiotic response element; hcit; homocitrulline; NC-XRE; non-consensus xenobiotic response element; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; KLF6; Krüppel-like factor 6; CPS1; carbamoyl phosphate synthase 1;
Keywords: Ovarian cancer; Chemotherapy resistance; Natural compounds; Autophagy; Apoptosis; Ovarian cancer stem-like cells; ABCG2; ATP-binding cassette G2; AE; Amla extracts; Akt; protein kinase B; ALDH1; aldehyde dehydrogenase 1; ARE; antioxidant-response element;
Keywords: Q3G; quercetin 3-O-β-glucoside; Q4â²G; quercetin 4â²-O-β-glucoside; OPAC; 3-hydroxyphenylacetic acid; DOPAC; 3,4-dihydroxyphenylacetic acid; PCA; protocatechuic acid (3,4-dihydroxybenzoic acid); HPA; hippuric acid; DPPH; 1,1-diphenyl-2-picrylhydrazyl;
Keywords: AhR; aryl hydrocarbon receptor; AhRR; aryl hydrocarbon receptor repressor; ARNT; AhR nuclear translocator; B[a]P; Benzo[a]Pyren; Ct; total carbon; CYP1A1; cytochrome P4501A1; CYP1B1; cytochrome P4501B1; s; double strand breaks; DL; detection limit; LDH; l
Canonical and non-canonical mechanisms of Nrf2 activation
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; ATF4; activating transcription factor 4; Atg5; autophagy protein 5; Atg7; autophagy protein 7; Bach; BTB and CNC homology; CBP; CREB binding protein; CHD6; chromodomain-
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
Keywords: AhR; aryl hydrocarbon receptor; ARNT; ah receptor nuclear translocator protein; ATP; adenosine triphosphate; ASC; apoptosis-associated speck-like protein containing CARD; BMDM; bone marrow-derived macrophage; BSA; bovine serum albumin; Caspase-1; cysteiny
Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner
Keywords: Ab; antibody; AhR; aryl hydrocarbon receptor; APC; antigen-presenting cell; ARNT; AhR nuclear translocator; BaP; benzo(a)pyrene; BMDCs; bone-marrow derived dendritic cells; BMMs; bone-marrow derived macrophages; CD; cluster of differentiation; CYP 450; cy
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
Keywords: Nrf2 activation; Pyridone; Enone; Aldol condensation; Nrf2; nuclear factor erythroid 2 related factor 2; CNS; central nervous system; Keap1; Kelch-like ECH associated protein 1; NF-κB; nuclear factor kappa-light-chain enhancer of activated B cells; Maf;
Multiple resistance to pirimiphos-methyl and bifenthrin in Tribolium castaneum involves the activity of lipases, esterases, and laccase2
Keywords: E1; esterase1; LIPs; lipases; LACs; laccases; Pyr; pyrethroid; Org; organophosphate; F1Pyr and F5Pyr; beetles selected throughout one or five generations in the presence of bifenthrin (pyrethroid), respectively; F1Org and F5Org; beetles selected throughou
Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats
Keywords: AhR; aryl hydrocarbon receptor; AREG; amphiregulin; E2; estradiol; ER; estrogen receptor; HT; hormone therapy; IX; isoxanthohumol; MNU; methylnitroso urea; OVX; ovariectomy or ovariectomized; 6-PN; 6-prenylnaringenin; 8-PN; 8-prenylnaringenin; PND; postna
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
Keywords: Sirtuin 1 (SIRT1); skin barrier; filaggrin; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; ARNT; Aryl hydrocarbon receptor nuclear translocator; BaP; Benzo(a)pyrene; cHet; Epidermis-specific heterozygous SIRT1 deletion; cKO; Epidermis-specific hom
Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; B(a)P; benzo(a)pyrene; bHLH/PAS; basic helix-loop-helix/PER-ARNT-SIM; CoCl2; cobalt chloride; CYP1A1; cytochrome P450 1A1; HIF-1α; hypoxia-inducible factor-1α; HRE; hy
The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway
Keywords: Ahr; aryl hydrocarbon receptor; AIP; Ahr-interacting protein; ALP; alkaline phosphatase; ARNT; aryl hydrocarbon receptor nuclear translocator; BMD; bone mineral density; CFA; complete Freund's adjuvant; CH-223191; 2-methyl-2H-pyrazole-3-carboxylic acid; C
Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down
Keywords: AhR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon repressor protein; α-NF; α-naphthoflavone; β-NF; β-naphthoflavone; CYP1A1; cytochrome P450 1A1; ITE; 2-(1â²H-indole-3â²-carbonyl)-thiazole-4-carboxylic acid methyl ester; TCDD; 2,3,7,8-tetrachlo
Research ArticleGender matters: Estrogen receptor alpha (ERα) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A)
Keywords: UGT; UDP-glucuronosyltransferase; ERα; estrogen receptor alpha; AhR; arylhydrocarbon receptor; Nrf2; nuclear factor erythroid related factor 2; XRE; xenobiotic response element; TCDD; 2,3,7,8-tetrachlordibenzo-p-dioxin; tBHQ; tert-butylhydroquinone; PCR;
β-Catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells
Keywords: ARNT; Ah receptor nuclear translocator; bHLH; basic helix-loop-helix; CTF2; E-cadherin carboxy terminal fragment 2; CYP1A1; cytochrome P-450 1A1; DAPT; N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; EMT; epithelial-mesenchymal tr
Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: A role of heme oxygenase-1
Keywords: AhR; aryl hydrocarbon receptor; MeHg; methyl mercury chloride; CYPs; cytochrome P450s; HO-1; heme oxygenase-1; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); XRE; xenobiotic responsive element; ARE; antioxidant responsive element; SnMP; Tin mesoporphyr
Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localization
Keywords: TG2; transglutaminase 2; HIF; hypoxia inducible factor; HRE; hypoxia response element; XRE; xenobiotic response element; OGD; oxygen glucose deprivation; NLS; nuclear localization signal; NES; nuclear export signal; CAT; catalytic; ChIP; chromatin immunop
TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: A cautionary tale of the use of this cell line in studies on dioxin toxicity
Keywords: AhR; aryl hydrocarbon receptor; AKT1S1; proline-rich AKT1 substrate 1; CYP1A1; cytochrome P450 1A1; 4E-BP1; eukaryotic translation initiation factor 4E-binding protein 1; ERK; extracellular signal-regulated protein kinase; GSK3; glycogen synthase kinase 3
Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors
Keywords: AhR; Ah receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; FXR; farnesoid receptor; GST; glutathione S-transferase; HETE; hydroxyeicosatetraenoic acid; LATF; ligand-activated transcription factor; LTB4; leucotriene B4; PPAR; peroxisome
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I
Keywords: AHR; aryl hydrocarbon receptor; AA; aristolochic acid; AAI; aristolochic acid I; AAIa; aristolochic acid Ia; AAN; aristolochic acid nephropathy; ARE; antioxidant response element (also known as EpRE, electrophile response element); BEN; Balkan endemic nep
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms
Keywords: AhR; aryl hydrocarbon receptor; Act-D; actinomycin D; BaP; benzo(a)pyrene; CHX; cycloheximide; CYP; cytochrome P450; EMSA; electrophoretic mobility shift assay; 7ER; 7-ethoxyresorufin; EROD; 7-ethoxyresorufin O-deethylase; GAPDH; glyceraldehyde-3-phosphat
Induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works—Possible roles of aryl hydrocarbon receptor agonists and oxidative stress
Keywords: Carbonyl reductase/20β-hydroxysteroid dehydrogenase; Oxidative stress; AhR ligand; XRE; ARE; Sewage treatment plants
The carotenoid lycopene differentially regulates phase I and II enzymes in dimethylbenz[a]anthracene-induced MCF-7 cells
Keywords: Lycopene; CYP1A1; CYP1B1; UGT1A1; XRE
Prunus armeniaca L (apricot) protects rat testes from detrimental effects of low-dose x-rays
Keywords: CAT; catalase; DPPH; 1,1-diphenyl-2-picrylhydrazyl; GSH-Px; reduced glutathione; ROS; reactive oxygen species; RSP; radical scavenging power; SOD; superoxide dismutase; TBARS; thiobarbituric acid-reactive substances; TPC; total phenolic content; XRE; X-ra
TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes
Keywords: VEGF; vascular endothelial growth factor; VEGFR; vascular endothelial growth factor receptor; TSU-16; (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; CYP; cytochrome P450; AhR; aryl hydrocarbon receptor; OMP; omeprazole; 3MC; 3-methylcholanthr
Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes-An in vitro study
Keywords: PAHs; Polycyclic aromatic hydrocarbons; B(a)P; Benzo(a)pyrene; QD; Quinone derivatives; ROS; Reactive oxygen species; LPO; Lipid peroxidation; PO; Protein oxidation; GSH; Reduced glutathione; GSSG; Oxidised glutathione; GR; Glutathione reductase; GPx; Glu
Coffee Induces Expression of Glucuronosyltransferases by the Aryl Hydrocarbon Receptor and Nrf2 in Liver and Stomach
Keywords: Liver Cancer; Glucuronidation; Coffee; ARE; antioxidant response element; HCC; hepatocellular carcinoma; Nrf2; nuclear factor erythroid-related factor 2; PCR; polymerase chain reaction; siRNA; short interfering RNA; tBHQ; tert-butylhydroquinone; TCDD; 2,3
Estrogenic status modulates the effect of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA)
Keywords: AhR; aryl hydrocarbon receptor; E2; estradiol; ER; estrogen receptor; CYP1A1; cytochrome P-450-1A1; DMBA; 7,12-dimethylbenz [a] anthracene; OVX; ovariectomized; PAHs; polycyclic aromatic hydrocarbons; PND; post natal day; SPI; soy protein isolate; XRE; xe
Repression of Ah receptor and induction of transforming growth factor-β genes in DEN-induced mouse liver tumors
Keywords: ALDH3A1; aldehyde dehydrogenase-3A1; AHR; aryl hydrocarbon receptor; AHRE; aryl hydrocarbon receptor response element; AIP; AHR-interacting protein; ALL; acute lymphoblastic leukemia; ARA9; Ah receptor-associated protein 9; ARNT; aryl hydrocarbon receptor
Shifted concentration dependency of EpRE- and XRE-mediated gene expression points at monofunctional EpRE-mediated induction by flavonoids at physiologically relevant concentrations
Keywords: Flavonoids; EpRE; XRE; AhR; Monofunctional and bifunctional inducers; NQO1
Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells
Keywords: FBS; fetal bovine serum; EROD; ethoxyresorufin-O-deethylase; AHR; aryl hydrocarbon receptor; XRE; xenobiotic response element; DMBA; 7,12-dimethylbenz[a]anthracene; PAH; polycylic aromatic hydrocarbon; Perillyl alcohol; Limonene; CYP1A1; CYP1B1; XRE; DMBA
Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway
Keywords: 26S proteasome; 3-Methylcholanthrene (3-MC); Bifunctional inducer; Nrf2; ARE; XRE; Expression; Reporter gene
Transcription factor NF2d9 (LBP-1a) interacts with the positive regulatory element for the xenobiotic responsive element
Keywords: 3-MC; 3-methylcholanthrene; AhR; arylhydrocarbon receptor; Arnt; AhR nuclear translocator; PREX; positive regulatory element for XRE-mediated gene expression; XRE; xenobiotic responsive element; Arylhydrocarbon receptor; CYP2A8; NF2d9; PREX; Xenobiotic re
CYP2S1: A short review
Keywords: BP; base pair(s); CE-SSCP; capillary electrophoresis single strand conformation polymorphism; CYP; cytochrome P450; PAH; polycyclic aromatic hydrocarbon; PCR; polymerase chain reaction; SNP; single nucleotide polymorphism; TCDD; 2,3,7,8-tetrachlorodibenzo
Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes
Keywords: AhR; aryl hydrocarbon receptor; Arnt; aryl hydrocarbon receptor nuclear translocator protein; CYP; cytochrome P450; cDNA; complementary DNA; DCFH-DA; 2,7-dichrolofluorescin diacetate; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Hsp; heat shock protei
Hydroxychalcones exhibit differential effects on XRE transactivation
Keywords: XRE; xenobiotic responsive element; B[a]P; benzo[a]pyrene; PAH; polycyclic aromatic hydrocarbon; AHR; aryl hydrocarbon receptor; DMBA; 7,12-dimethylbenz[a]anthracene; GSH; glutathione; EROD; ethoxyresorufin-O-deethylase; EDTA; ethylenediaminetetra-acetic