کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5739166 1615360 2017 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
ترجمه فارسی عنوان
عوارض جانبی داروهای مرتبط با آمفتامین در انسان و حیوانات آزمایشی: مکانیسم اصلی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and non-human primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 155, August 2017, Pages 149-170
نویسندگان
, , , , , , , , ,