Keywords: AB-MECA; (N6-(4-aminobenzyl)-N-methylcarboxamidoadenosine); AC; adenylate cyclase; AR; adenosine receptor; CHO; Chinese Hamster Ovary; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; MV; molecular volume; NECA; 5â²-(N-ethylcarboxamido)adenosine; TPSA; Topolog
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Keywords: Dopamine; Ecstasy; Methamphetamine; METH; 3,4-Methylenedioxymethamphetamine; MDMA; Mouse; Neurodegeneration; Neuroinflammation neurotoxicity; Non-human primate; Rat; AC; adenylyl cyclase; AcbSh; nucleus accumbens shell; AcbC; nucleus accumbens core; cAMP;
Keywords: cAMP; cyclic adenosine monophosphate; CNS; central nervous system; DPCPX; 8-Cyclopentyl-1,3-dipropylxanthine; EAA; excitatory amino acid; EAAT; excitatory amino acid transporter; NMDA; N-methyl-d-aspartate; TTBS; Tween 20 Tris-Buffered Saline; adenosine;
Keywords: A1R; adenosine A1 receptors; DMSO; dimethylsulfoxide; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; EC; entorhinal cortex; fEPSP; field excitatory postsynaptic potentials; FST; forced swimming test; GABA; γ-aminobutyric acid; HRMAS; high-resolution magic an
Keywords: AD; Alzheimer disease; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; DMSO; dimethylsulfoxide; EHNA; erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride; ZM 241385; 4-(2-[7-amino-2-{2-furyl}{1,2,4}triazolo-{2,3-a}{1,3,5}triazin-5-yl-amino]ethyl) phenol; Adeno
Keywords: A1R; adenosine receptor type 1; A2AR; adenosine receptor type 2A; Ado; adenosine; APV; d-(â)-2-amino-5-phosphonopentanoic acid; ATP; adenosine triphosphate; CGS-21680; 4-[2-[[6-amino-9-(N-ethyl-β-d-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benze
Keywords: CPA; N(6)-cyclopentyl-adenosine; DPCPX; 8-cyclopentyl dipropyixanthine; EPCs; end-plate currents; m; quantal content; MEPCs; miniature end-plate currents; NAC; N-acetyl-cysteine; ROS; reactive oxygen species; neuromuscular junction; kinetics of transmitte
Keywords: AR; adenosine receptor; cAMP; cyclic adenosine 3â²,5â²-monophosphate; BODIPY; boron-dipyrromethene; CFP; cyan fluorescent protein; CHO; Chinese hamster ovary; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; FCM; flow cytometry; FCS; fluorescence correlation
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1 and A2A adenosine receptor antagonists/inverse agonists
Keywords: AR; adenosine receptor; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopentyl-1,3-dipropyl-xanthine; I-AB-MECA; 4-[((4-amino-3-iodophenyl)methyl)amino]-5â²-N-methylcarboxamidoadenosine; ZM 241385; (4-(2-[7-amino
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor
Keywords: G protein-coupled receptors; Adenosine A2B receptor agonists; Aminopyridine-3,5-dicarbonitriles; Ligand-adenosine receptor modelling studies; ABMECA; N6-(4-aminobenzyl)N-methylcarboxamidoadenosine; Ado; Adenosine; AR; adenosine receptor; CHO; Chinese hams
Cardiac arrest induced by muscarinic or adenosine receptors agonists is reversed by DPCPX through double mechanism
Keywords: Adenosine (PubChem CID: 60961); ATP (PubChem CID: 5957); N6Cyclopentyladenosine (CPA) (PubChem CID: 657378); Acetylcholine (PubChem CID: 187); Carbachol (PubChem CID: 5831); 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) (PubChem CID: 1329); Atropine (PubChem
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor
Keywords: G protein coupled receptors; A2A adenosine receptors; Inverse agonists; Thiazolopyrimidine derivatives; Bicyclic heteroaromatic system; AR; adenosine receptor; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopenty
Development and validation of a LC-MS/MS assay for quantification of cisplatin in rat plasma and urine
Keywords: DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; CS; calibrationstandards; DDTC; diethyldithiocarbamate; ESIEl; ectrospray ionization; FDA; Food and Drug Administration; HPLC; High performance liquid chromatography; ICP-MS; induction coupled mass spectrometry;
Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A1 receptors
Keywords: Paeoniflorin; Paclitaxel; Allodynia; Adenosine A1 receptor; PTX; paclitaxel; PF; paeoniflorin; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; A1R; adenosine A1 receptor; DPCPX; 8-cyclopentyl-1,3-diprooylxanrhine; GAPDH; glyceraldehyde 3-phosph
Differential spread of anoxic depolarization contributes to the pattern of neuronal injury after oxygen and glucose deprivation (OGD) in the Substantia Nigra in rat brain slices
Keywords: 9AA; 9-aminoacridine; ACSF; artificial cerebrospinal fluid; AD; anoxic depolarization; CMFDA; 5-chloromethylfluoroscein diacetate; DA; dopamine; DPCPX; dipropylcyclopentylxanthine; EC; energy charge; LT; light transmittance; MALDI MS; matrix assisted lase
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes
Keywords: G protein-coupled receptors; Adenosine receptor antagonists; Imidazopyrazines; Bicyclic heteroaromatic systems; Ligand-receptor modeling studies; AR; adenosine receptor; AB-MECA; N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine; NECA; 5'-(N-ethyl-carboxa
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats
Keywords: ARRIVE; Animal Research: Reporting of In Vivo Experiments; CTL; control; DC; direct current; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; Pilo; pilocarpine; PS; population spikes; RPia; (R)-N-phenylisopropyladenosine; SE; status epilepticus; SRS; spontaneou
Modulation of dopamine-mediated facilitation at the neuromuscular junction of Wistar rats: A role for adenosine A1/A2A receptors and P2 purinoceptors
Keywords: ATP; adenosine triphosphate; CGRP; calcitonin gene-related peptide; CSC; 8-(3-Chlorostyryl) caffeine; DMSO; dimethyl sulphoxide; DPCPX; 1,3-Dipropyl-8-cyclopentylxanthine; PKA; Protein Kinase A; SNARE; Soluble NSF (N-ethylmaleimide sensitive factor) Attac
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor
Keywords: G-protein-coupled receptors; Adenosine receptor antagonists; Pyrazolopyrimidines; Ligand-receptor modeling studies; AR; adenosine receptor; NECA; 5â²-(N-ethyl-carboxamido)adenosine; cAMP; cyclic adenosine monophosphate; Cl-IB-MECA; 2-chloro-N6-(3-iodoben
Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury
Keywords: Hippocampal neurotoxicity; Cerebral ischemia; Adenosine A1 receptor; AMPAR trafficking; Serine/threonine protein phosphatase; Adenosine-induced persistent synaptic depression; CPA; N6-cyclopentyl adenosine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; APSD;
Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety
Keywords: Adenosine; Anxiety; Positive allosteric modulation; TRR469; Benzodiazepines; A1 receptors; AR; adenosine receptor; CCPA; 2-chloro N(6)-cyclopentyladenosine; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; LORR; loss of righting reflex; PD 81,723; (2-amino-4,5-
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice
Keywords: A1; adenosine receptor type 1; A2A; adenosine receptor type 2A; A3; adenosine receptor type 3; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AOPCP; É,β-methyleneadenosine 5â²-diph
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors
Keywords: AR; adenosine receptor; PD; Parkinson's disease; CCPA; 2-chloro-N(6)-cyclopentyladenosine; NECA; 5â²-(N-ethyl-carboxamido)adenosine; cAMP; cyclic adenosine monophosphate; Cl-IB-MECA; 2-chloro-N6-(3-iodobenzyl)5â²-(N-methylcarbamoyl)adenosine; DPCPX; 8
Research reportAdenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain
Keywords: CNS; central nervous system; NMDA; N-methyl-d-aspartate; A1R; A1 receptors; PKA; protein kinase A; PI3K; phosphatidylinositol-3 kinase; CPA; cyclo-pentyl-adenosine; CCPA; 2-chloro-N6-cyclopentyl-adenosine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; KRB; K
Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281
Keywords: CCPA; 2-chloro-N(6)-cyclopentyladenosine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; ENT1; equilibrative nucleoside transporter subtype 1; Gö6983; 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; GPI-GFP; gl
Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Keywords: Residence time; Structure-affinity relationships; Structure-kinetics relationships; Adenosine A1 receptor; Extracellular loops; ADA; adenosine deaminase; Ac; acetyl; BCA; bicinchoninic acid; BEDROC; Boltzmann-enhanced discrimination of receiver-operating
Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A2A receptors and redistribution of synaptic vesicles
Keywords: Neuromuscular junction; Synaptic vesicle recycling; Acetylcholine release; Glucocorticoids; Adenosine receptors; Muscarinic receptors; ACh; acetylcholine; ADA; adenosine deaminase; DPCPX; 1,3-dipropyl-8-cyclopentyl xanthine; Dyngo-4a; 3-Hydroxy-N'-[(2,4,5
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation
Keywords: G protein-coupled receptors; Adenosine receptor antagonists; Thiazolopyrimidine; Bicyclic heteroaromatic systems; Ligand-receptor modeling studies; MRS 1220; 9-Chloro-2- (2-furanyl)-5-((phenylacetyl)amino)- [1,2,4]triazolo[1,5-c]quinazoline; NECA; 5â²-N-
Transferred inter-cell ischemic preconditioning-induced neuroprotection may be mediated by adenosine A1 receptors
Keywords: DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; LDH; lactate dehydrogenase; OGD; oxygen-glucose deprivation; Adenosine A1 receptor; Akt; Inter-cell preconditioning; Neuroprotection;
The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells
Keywords: Caffeine; adenosine A2A antagonist; CHOP; C/EBP homologous protein; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine, adenosine A1 antagonist; Cor; cordycepin; ER; endoplasmic reticulum; Glu; glutamate; IRE1α; inositol-requiring enzyme 1α; MAPKs; mitogen-activ
Cardiovascular pharmacologyInhibition of pre-ischeamic conditioning in the mouse caudate brain slice by NMDA- or adenosine A1 receptor antagonists
Keywords: Dopamine; Voltammetry; MK-801; DPCPX; TTC; HPLC;
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: Evidence for a role of the adenosinergic system
Keywords: ANOVA; analysis of variance; AR; adenosine receptor; CPIP; chronic post-ischemic pain; CRPS-I; complex regional pain syndrome type I; DMSO; dimethylsulfoxide; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; EHNA; erythro-9-(2-hydroxy-3nonyl) adenine; IMP; inos
Crude extract and purified components isolated from the stems of Tinospora crispa exhibit positive inotropic effects on the isolated left atrium of rats
Keywords: Tinospora crispa; Left atria; Higenamine; Tyramine; ICI-118,551; DPCPX;
Evidence for constitutive protein synthesis in hippocampal LTP stabilization
Keywords: ACSF; artificial cerebrospinal fluid; AP-5; d-(â)-2-amino-5-phosphonopentanoic acid; CHX; cycloheximide; DMSO; dimethysulfoxide; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; fEPSP; field excitatory postsynaptic potentials; FeSO4; ferrous sulfate; H2O2; hy
Osteopontin inhibits osmotic swelling of retinal glial (Müller) cells by inducing release of VEGF
Keywords: BAPTA-AM; bis-(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetra-acetic acid acetoxymethyl ester; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; GDNF; glial cell line-derived neurotrophic
Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling
Keywords: ADA; adenosine deaminase; A1R; adenosine A1 receptors; A2AR; adenosine A2A receptors; A2BR; adenosine A2B receptors; A3R; adenosine A3 receptors; ALP; alkaline phosphatase; ARS; Alizarin Red S staining; CCPA; 2-chloro-N6-cyclopentyladenosine; CGS21680; 2-
Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons
Keywords: C4; fourth cervical; CPA; cyclopiazonic acid; DMPX; 3,7-dimethyl-1-propargylxanthine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; Hepes; hydroxyethyl piperazineethanesulfonic acid; IRCs; ictal respiratory changes; P; postnatal day; PDE4; phosphodiesterase-
Interaction of δ and κ opioid receptors with adenosine A1 receptors mediates cardioprotection by remote ischemic preconditioning
Keywords: IPC; Ischemic preconditioning; rIPC; Remote ischemic preconditioning; DPCPX; 8-Cyclopentyl-1,3-dipropylxanthine; MRS1523; 3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate; NTI; Naltrindole hydrochloride; GNTI; 5â²-Guanidi
Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway
Keywords: BK; large (big) conductance Ca2+-activated K+ channels; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; GUO; guanosine; GSK-3β; glycogen synthase kinase 3β; H2DCFDA; 2â²,7â²-dichlorofluorescein diacetate; HO-1; heme oxygenase-1; LY294002; 2-(4-morpholinyl)
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: Role of adenosine A1 receptor
Keywords: ATP; adenosine triphosphate; DPCPX; 8-cyclopentyl-1,3-dipropyl-xanthine; EHNA; erythro-9 (2-hydroxy-3-nonyl)-adenine; NBMPR; p-nitro-benzylthioinosine; SPT; 8-(p-sulfophenyl)theophyline;
Downregulation of A1 and A2B adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi
Keywords: CV; chorionic villi; DPCPX; 1,3-dipropyl-8-cyclopentyl-xanthine; MC; mesenchymal cells; MRE 2029-F20; N-benzo[1,3]dioxol-5-yl-2-[5-(1,3-dipropyl-2,6-dioxo-2,3,6,7-tetrahydro-1Â H-purin-8-yl)-1-methyl-1Â H-pyrazol-3-yl-oxy]-acetamide]; MRE 3008-F20; 5-N-(4
Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation
Keywords: fEPSP; field excitatory postsynaptic potential; A1; adenosine receptor 1; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; DAB; 1, 4-dideoxy-1,4-imino-d-arabinitol; NJM; 1-deoxyjirinomycin; ACSF; artificial cerebrospinal fluid; CA1; cornu ammonis region 1; DG;
Purinergic modulation of the excitatory synaptic input onto rat striatal neurons
Keywords: Striatal medium spiny neurons; NMDA receptors; ATP; Adenosine; Presynaptic purinergic modulation; Postsynaptic purinergic modulation; ADA; adenosine deaminase; AMPA; (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP-5; d,l-2-amino-5-phosphonop
Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors
Keywords: AIDA; (RS)-1-Aminoindan-1,5-dicarboxylic acid; AM251; N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; CsMeSO3; caesium methanesulfonate; D-600; methoxy-verapamil; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; EP
A1 adenosine receptor modulation of chemically and electrically evoked lumbar locomotor network activity in isolated newborn rat spinal cords
Keywords: 5-HT; serotonin; ADO; adenosine; ADP; adenosine diphosphate; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CPG; central pattern generator; CV; coefficient of variation; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; GABAA receptor; A-type
Pharmacological analysis of zebrafish (Danio rerio) scototaxis
Keywords: 5-HT; 5-hydroxytryptamine,serotonin; DPCPX; 8-Cyclopentyl-1,3-dirpopylxnathine; LSD; Lysergic acid diethylamide; MAO-A; Monoamine oxidase A; SERT; Serotonin transporter; SSRI; Selective serotonin reuptake inhibitor; Anxiety; Light/dark preference; Zebrafi
Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury
Keywords: ADP; adenosine diphosphate; AMP; adenosine monophophate; ATP; adenosine triphosphate; MI; myocardial infarction; ENTPD-1 CD39; ectonucleoside triphosphate diphosphohydrolase 1; Akt; serine/threonine protein kinase; ERK 1/2; extracellular signal-regulated
Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors
Keywords: ATP; benzoylbenzoyl ATP; brilliant blue G; minocycline; mustard oil; periodated oxidized ATP; ANOVA; analysis of variances; BBG; brilliant blue G; BzATP; 2â²3â²-o-(4-benzoylbenzoyl) adenosine 5â²-triphosphate (ATP); DPCPX; 8-cyclopentyl-1,3-dipropylxan
Adenosinergic system is involved in development of diazepam tolerance in mice
Keywords: cAMP; cyclic adenosine monophosphate; CGS 21680; 2-p-(2-carboxyethyl)phenethylamino-5â²-N-ethylcarboxamidoadenosine hydrochloride; CPA; N6-cyclopentyladenosine; DMPX; 3,7-dimethyl-1-(2-propynyl)-xanthine; DPCPX; 1,3-dipropyl-8- cyklopentylxanthine; GABA;
Synergism of theophylline and anticholinergics to inhibit haloperidol-induced catalepsy: A potential treatment for extrapyramidal syndromes
Keywords: AC; adenylyl cyclase; ACh; acetylcholine; A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; ANOVA; analysis of variance; BENZ; benztropine; CDT; cumulative descent time; CNS; central nervous system; DMSO; dimethylsulphoxyde; DPCPX; 8-cyclopentyl-1