Downregulation of A1 and A2B adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi

► Adenosine receptors (ARs) have never been characterized in aneuploid pregnancies. ► Here ARs were investigated in euploid and trisomy 21 chorionic villi and mesenchymal cells. ► Reduced A1 and A2B expression was revealed in aneuploid chorionic villi and mesenchymal cells. ► A1 and A2BARs increasing NO and VEGF secretion may improve fetoplacental perfusion.