Keywords: AB-MECA; (N6-(4-aminobenzyl)-N-methylcarboxamidoadenosine); AC; adenylate cyclase; AR; adenosine receptor; CHO; Chinese Hamster Ovary; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; MV; molecular volume; NECA; 5â²-(N-ethylcarboxamido)adenosine; TPSA; Topolog
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Keywords: Betamethasone; Fetal programming; Adenosine; Sinoatrial node; Ischemia; Infarct; BET; betamethasone; RA; right atrium; I/R; ischemia/reperfusion; NECA; 5â²-(N-ethylcarboxamido)adenosine; 2-Cl-adenosine; 2-chloro-adenosine; SAN; sinoatrial node; TTC; 2,3,
Keywords: AR; adenosine receptor; cAMP; cyclic adenosine 3â²,5â²-monophosphate; BODIPY; boron-dipyrromethene; CFP; cyan fluorescent protein; CHO; Chinese hamster ovary; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; FCM; flow cytometry; FCS; fluorescence correlation
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1 and A2A adenosine receptor antagonists/inverse agonists
Keywords: AR; adenosine receptor; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopentyl-1,3-dipropyl-xanthine; I-AB-MECA; 4-[((4-amino-3-iodophenyl)methyl)amino]-5â²-N-methylcarboxamidoadenosine; ZM 241385; (4-(2-[7-amino
Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor⢠biosensor: Evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603
Keywords: A2AAR; A2A adenosine receptor; A2BAR; A2B adenosine receptor; BAY 60-6583; (2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; HEK293G; Human Embryonic Kidney 293 cell line stably expressing the GloSensor⢠biosensor; D
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor
Keywords: G protein-coupled receptors; Adenosine A2B receptor agonists; Aminopyridine-3,5-dicarbonitriles; Ligand-adenosine receptor modelling studies; ABMECA; N6-(4-aminobenzyl)N-methylcarboxamidoadenosine; Ado; Adenosine; AR; adenosine receptor; CHO; Chinese hams
Neuropharmacological effects of essential oil from the leaves of Croton conduplicatus Kunth and possible mechanisms of action involved
Keywords: ATP; atropine; CNS; central nervous system; DZP; diazepam; EO; essential oil (EO); EPM; elevated plus maze; FLU; flumazenil; GC-MS; gas chromatograph interfaced to a mass spectrometer; INDO; indomethacin; MOR; morphine; NECA; number of entries in the clos
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor
Keywords: G protein coupled receptors; A2A adenosine receptors; Inverse agonists; Thiazolopyrimidine derivatives; Bicyclic heteroaromatic system; AR; adenosine receptor; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopenty
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype
Keywords: G protein-coupled receptor; Adenosine receptor; A3 antagonist; [1,2,4]triazolo[1,5-c]pyrimidine; Molecular modeling; Docking; AR; adenosine receptor; cAMP; cyclic adenosine monophosphate; CCPA; 2-chloro-N6-cyclopentyladenosine; CHO; chinese hamster ovary;
On the G protein-coupling selectivity of the native A2B adenosine receptor
Keywords: BAY60-6583; 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CE3F4; 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde; CGS21680; 2-[p-(2-carboxyethy
Tools and drugs for uracil nucleotide-activated P2Y receptors
Keywords: ADP; Adenosine 5â²-diphosphate; AP4A; P1,P4-Di(adenosine-5â²)-tetraphosphate; AR; Adenosine receptor; AR-C118925; 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarbo
A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment
Keywords: A2aR; adenosine A2a receptor; CAF; cancer-associated fibroblast; CHO; Chinese hamster ovary; IC50; concentration of compound that displaces the binding of radioligand by 50%; Kb; binding constant; Ki; inhibition constant; NECA; 5â³-N-ethylcarboxamidoaden
Adenosine A2 receptor activation ameliorates mitochondrial oxidative stress upon reperfusion through the posttranslational modification of NDUFV2 subunit of complex I in the heart
Keywords: Adenosine A2 receptors; NECA; Superoxide; Src tyrosine kinase; Complex I; NDUFV2;
Involvement of adenosine A3 receptors in the chemotactic navigation of macrophages towards apoptotic cells
Keywords: A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; A2BR; adenosine A2B receptor; A3R; adenosine A3 receptor; MAPK; mitogen activated protein kinase; NECA; 5â²-N-ethylcarboxamidoadenosine; PI3K; phosphatidylinositol-3â²-kinase; Macrophage; Chemota
Adenosine A2A and A2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis
Keywords: AR; adenosine receptors; BAY; BAY60-6583; CGS; CGS-21680; iCa2+; intracellular calcium; MRS; MRS-1706; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NECA; 5'-N-ethylcarboxamidoadenosine; NHEK; normal human epidermal keratinocyte; SC
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes
Keywords: G protein-coupled receptors; Adenosine receptor antagonists; Imidazopyrazines; Bicyclic heteroaromatic systems; Ligand-receptor modeling studies; AR; adenosine receptor; AB-MECA; N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine; NECA; 5'-(N-ethyl-carboxa
Enhanced A2A adenosine receptor-mediated increase in coronary flow in type I diabetic mice
Keywords: Diabetes; coronary flow; A2A adenosine receptor; NECA; CGS 21680;
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor
Keywords: G-protein-coupled receptors; Adenosine receptor antagonists; Pyrazolopyrimidines; Ligand-receptor modeling studies; AR; adenosine receptor; NECA; 5â²-(N-ethyl-carboxamido)adenosine; cAMP; cyclic adenosine monophosphate; Cl-IB-MECA; 2-chloro-N6-(3-iodoben
Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B
Keywords: PBR; polybasic region; GEF; guanine nucleotide exchange factor; PKA; protein kinase A; Ctx; cholera toxin; GPCR; Gαs protein-coupled receptor; NECA; 5â²-N-ethylcarboxamidoadenosine; Iso; isoproterenol; GFP; green fluorescent protein; protein isoprenylat
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors
Keywords: AR; adenosine receptor; PD; Parkinson's disease; CCPA; 2-chloro-N(6)-cyclopentyladenosine; NECA; 5â²-(N-ethyl-carboxamido)adenosine; cAMP; cyclic adenosine monophosphate; Cl-IB-MECA; 2-chloro-N6-(3-iodobenzyl)5â²-(N-methylcarbamoyl)adenosine; DPCPX; 8
Pathophysiology of the hepoxilins
Keywords: AA; arachidonic acid; AMG9810; (2E)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide; Apaf-1; Apoptotic protease activating factor 1; BAPTA; 1,2-Bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; CCCP; carbonyl cya
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation
Keywords: G protein-coupled receptors; Adenosine receptor antagonists; Thiazolopyrimidine; Bicyclic heteroaromatic systems; Ligand-receptor modeling studies; MRS 1220; 9-Chloro-2- (2-furanyl)-5-((phenylacetyl)amino)- [1,2,4]triazolo[1,5-c]quinazoline; NECA; 5â²-N-
Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity
Keywords: 7TM; seven transmembrane spanning; A1R; adenosine A1 receptor; DVL; disheveled; FRAP; fluorescence recovery after photobleaching; FZD; Frizzled; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; NECA; 5â²-N-ethylcarboxamidoadenosine; NEM;
Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor
Keywords: GPCR; Adenosine receptor; Purines; Cyclic AMP; Calcium; Arrestin; BAY60-6583 (BAY, LUF6210); 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]acetamide; cyclic AMP (cAMP); 3â²5â²-cyclic adenosine monophosphate; CGS21680; 2-[p-(2
Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: Insight into the receptor activation switch
Keywords: NECA; adenosine-5â²-N-ethyluronamide; Ado; adenosine; GPCR; G protein-coupled receptor; AR; adenosine receptor; CCPA; 2-chloro-N6-cyclopentyladenosine; HEMADO; 2-hexyn-1-yl-N6-methyladenosine; CPA; N6-cyclopentyladenosine; HENECA; 2-hexyn-1-yl-adenosine-
Adenosine modulates LPS-induced cytokine production in porcine monocytes
Keywords: 2-CADO; 2-chloroadenosine; ARs; adenosine receptors; CPT; cyclopenthyltheophylline; CWS; cell washing solution; MFI; median of fluorescence intensity; N6-CPA; N6-cyclopenthyladenosine; NECA; N-ethylcarboxyamidoadenosine; Adenosine; Monocytes; Pig; TNF-α;
Potential role of A2A adenosine receptor in traumatic optic neuropathy
Keywords: TON; traumatic optic neuropathy; TNF-α; tumor necrosis factor-α; ELISA; Enzyme-linked immunosorbent assay; ROS; reactive oxygen species; MAP kinase; Mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; AR; adenosine receptor; CG
Multilevel pharmacological manipulation of adenosine-prostaglandin E2/cAMP nexus in the tumor microenvironment: A 'two hit' therapeutic opportunity
Keywords: AC; adenylyl cyclase; ATP; adenosine-5â²-triphosphate; ADP; adenosine-5â²-diphosphate; AMP; adenosine-5â²-monophosphate; CADO; 2-chloroadenosine; COX; cyclo-oxygenase; COXIBs; cyclo-oxygenase 2 (COX-2) inhibitors; CINODs; COX-inhibiting nitric oxide do
Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling
Keywords: ADA; adenosine deaminase; A1R; adenosine A1 receptors; A2AR; adenosine A2A receptors; A2BR; adenosine A2B receptors; A3R; adenosine A3 receptors; ALP; alkaline phosphatase; ARS; Alizarin Red S staining; CCPA; 2-chloro-N6-cyclopentyladenosine; CGS21680; 2-
Downregulation of A1 and A2B adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi
Keywords: CV; chorionic villi; DPCPX; 1,3-dipropyl-8-cyclopentyl-xanthine; MC; mesenchymal cells; MRE 2029-F20; N-benzo[1,3]dioxol-5-yl-2-[5-(1,3-dipropyl-2,6-dioxo-2,3,6,7-tetrahydro-1Â H-purin-8-yl)-1-methyl-1Â H-pyrazol-3-yl-oxy]-acetamide]; MRE 3008-F20; 5-N-(4
P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes
Keywords: 2MeSADP; 2-methylthio-ADP; 8PSPT; 8-(p-sulfophenyl)-theophylline; AD; Alzheimer's disease; APP; amyloid precursor protein; BzATP; 3â²-O-(4-benzoyl)benzoyl-ATP; DAPI; 4â²-6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; ERK; extracel
5â²-(N-ethylcarboxamido) adenosine improves angiogenesis in transplanted human ovarian tissue
Keywords: Angiopoietin; fertility preservation; human ovarian cortex; NECA; nude mice; transplantation; VEGF;
Adenosinergic system is involved in development of diazepam tolerance in mice
Keywords: cAMP; cyclic adenosine monophosphate; CGS 21680; 2-p-(2-carboxyethyl)phenethylamino-5â²-N-ethylcarboxamidoadenosine hydrochloride; CPA; N6-cyclopentyladenosine; DMPX; 3,7-dimethyl-1-(2-propynyl)-xanthine; DPCPX; 1,3-dipropyl-8- cyklopentylxanthine; GABA;
The critical role of intracellular zinc in adenosine A2 receptor activation induced cardioprotection against reperfusion injury
Keywords: A2 receptor; Intracellular zinc; NECA; Reperfusion injury; mPTP; Mitochondrial metabolism;
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process
Keywords: GPCRs; G protein-coupled receptors; AR; adenosine receptor; ADA; adenosine deaminase; cAMP; cyclic adenosine monophosphate; h; human; SAR; structure-affinity relationship; r; rat; DPCPX; 8-cyclopentyl-1,3-dipropyl-xanthine; CGS 21680; 2-[4-(2-carboxyeth
Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts
Keywords: NECA; Reperfusion injury; Adenosine A2 receptors; mPTP; GSK-3β;
Cellular NeuroscienceResearch PaperPurinergic modulation in the development of the rat uncrossed retinotectal pathway
Keywords: critical period; adenosine receptors; development; superior colliculus; cAMP; topographic order; EHNA; erythro-9(2-hydroxy-3-nonyl) adenine; HRP; horseradish peroxidase; NECA; 5â²-N-ethylcarboxamido-adenosine; PND; postnatal day; SC; superior colliculus;
Intranasal administration of NECA can induce both anti-inflammatory and pro-inflammatory effects in BALB/c mice: Evidence for A2A receptor sub-type mediation of NECA-induced anti-inflammatory effects
Keywords: NECA; Anti-inflammatory; A2A receptors; Adenosine; Mice; Asthma; Airway
CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism
Keywords: Contact hypersensitivity; regulatory T cells; adenosine; endothelial cells; skinfold chamber; AMP; Adenosine monophosphate; APC; Antigen-presenting cell; ATP; Adenosine 5â²-triphosphate disodium salt; CHS; Contact hypersensitivity; EC; Endothelial cell;
Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects
Keywords: Human mast cells; vascular endothelial growth factors; vascular endothelial growth factor receptors; angiogenesis; prostaglandin E2; adenosine; chemotaxis; CAM; Chorioallantoic membrane; CBMC; Cord blood-derived mast cell; GAPDH; Glyceraldehyde-3-phosph
Purinergic actions on neurons that modulate nociception in the rostral ventromedial medulla
Keywords: purines; rostral ventromedial medulla; nociception; electrophysiology; BSA; bovine serum albumin; NECA; 5â²-(N-ethylcarboxamido) adenosine; PB; phosphate buffer; PPADS; pyridoxal-phosphate-6-azophenyl-2â²,4â²disulphonic acid; RVM; rostral ventromedial
Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion
Keywords: Adenosine A2b receptors; BAY 60-6583; NECA; Preconditioning; Protein kinase C
Activation of Src/kinase/phospholipase c/mitogen-activated protein kinase and induction of neurite expression by ATP, independent of nerve growth factor
Keywords: ATP; P2Y receptor; MAP kinase; neurite outgrowth; neuro2a cells; BSA; bovine serum albumin; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; MEK; MAP kinase/ERK kinase kinase; MAPK; mitogen-activated protein kinase; NECA; 5â²
The role of adenosine A2A and A2B receptors in the regulation of TNF-α production by human monocytes
Keywords: 2-Cl-IB-MECA; 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-b-d-ribofuranuronamide; CCPA; 2-chloro-N6-cyclopentyladenosine; CGS21680; 4-[2-[[6-Amino-9-(N-ethyl-b-d-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropa
Adenosine receptor mediates nicotine-induced antinociception in formalin test
Keywords: Nicotine; NECA; Theophylline; Formalin test; Mice;
Stimulation of the proximal tubule Na+-ATPase activity by adenosine A2A receptor
Keywords: Na+-ATPase; Adenosine; Adenosine receptor; Proximal tubule; PKA; EDTA; ethylenediaminetetraacetic acid; HEPES; (N-2-hydroxyethylpiperazine Nâ²-2-ethanesulfonic acid); Tris; tris(trishydroxymethyl)-aminomethane; ATP; adenosine triphosphate (sodium salt);
Interaction between adenosine A2B-receptors and α2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: Possible involvement of a group 2 adenylyl cyclase isoform
Keywords: 2â²,5â²-dd-Ado; 2â²,5â²-dideoxyadenosine; 8-Br-cAMP; 8-bromoadenosine-3â²,5â²-cyclicAMP; 9-CP-Ade; 9-(cyclopentyl)-adenine; AC; adenylyl cyclase; ADA; adenosine deaminase; CaM; calmodulin; 1,9-dd-FOSK; 1,9-dideoxyforskolin; DPCPX; 8-cyclopentyl-1,3-