Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

Using a molecular simplification approach, a novel series of triazolotriazine differently substituted at the C5 and N7 has been synthesized and pharmacologically characterized as adenosine receptor antagonists.