Comparative efficacy and bioavailability of different praziquantel brands

► Biltricide, Distocide, PZQ T3A showed higher dissolution than Epiquantel and Bilharzid. ► Biltricide, Distocide showed higher Cmax and AUC with higher efficacy vs S. mansoni. ► Bilharzid, Epiquantel showed lower t1/2e, Cmax, AUC and efficacy vs S. mansoni. and higher Kel. ► Quality of generic PZQ should include bioavailability, efficacy and physicochemical tests.