Keywords: Dihydroorotate dehydrogenase; DHODH; Plasmodium falciparum; Inhibitor;
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Keywords: AST; aspartate transaminase; ALT; alanine transaminase; CYP; cytochrome-P450; Cyt C; cytochrome C; DHO; dihydroorotic acid; DHODH; DHO dehydrogenase; EDTA; ethylenediamine-tetraacetic acid; FMN; flavin mononucleotide; GGT; gamma-glutamyl transferase; LC-M
Keywords: DHODH; Resazurin; Fluorescence; Assay development; HTS; MalariaDHODH, dihydroorotate dehydrogenase; L-DHO, l-dihydroorotate; PfDHODH, Plasmodium falciparum DHODH; FMN, flavin mononucleotide; CoQD, ubiquinone; mETC, mitochondrial electron transport chain;
Keywords: ACIII; Alternative Complex III; ADH; Alcohol dehydrogenase; ALDH; Aldehyde dehydrogenase; AMO; Ammonia monooxygenase; AOX; Alternative oxidase; CISM; Complex Iron-Sulfur Molybdoenzyme; DAADH; d-amino acid dehydrogenase; DHODH; dihydroorotate dehydrogenase
Keywords: I; complex I; II; complex II; III; complex III; IV; complex IV; α-KGDH; α-ketoglutarate dehydrogenase; AO; alternative oxidase; cyt; cytochrome; DHODH; dihydroorotate dehydrogenase; ETF; electron transfer flavoprotein; GLRX; glutaredoxin; GPx; glutathio
Keywords: Drug development; Translational research; Inflammatory bowel disease; Colitis; Biomarkers; Endpoints; AA; alternative approaches; CD; Crohn's disease; 3Rs; Replacement, Reduction, Refinement; DHODH; dihydroorotate dehydrogenase; DNBS; dinitrobenzene sulph
Optimizing conventional DMARD therapy for Sjögren's syndrome
Keywords: 6-MP; 6-mercaptopurine; 6-T-GTP; 6-thioguanine triphosphate; ABT; abatacept; Ach; acetylcholine; ALAT; alanine amino transferase; AZA; azathioprine; BAFF; B cell activating factor; Bcl-6; B cell lymphoma 6; bDMARDs; biological disease modifying antirheuma
Leflunomide prevents ROS-induced systemic fibrosis in mice
Keywords: Ab; Antibody; AOPP; Advanced oxidation protein products; AU; Arbitrary Unit; mAb; monoclonal Antibody; DHODH; dihydro-orotate dehydrogenase; ECM; Extracellular matrix; FCS; Fetal calf serum; HOCl; Hypochlorous acid; KLF; Krüppfel-like Factor; PBS; Phosph
Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells
Keywords: ATP; Breast cancer; Dihydroorotate dehydrogenase; Normal cells and reactive oxygen species production; ATP; Adenosine triphosphate; ROS; Reactive oxygen species; DHODH; Dihydroorotate dehydrogenase; LFM; Leflunomide; BQR; Brequinar sodium; DMSO; Dimethyl
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials
Keywords: Malaria; Dihydroorotate dehydrogenase (DHODH); Pyrimidine biosynthesis; Plasmodium parasite; Drug resistance; DHODH; dihydroorotate dehydrogenase; PfDHODH; Plasmodium falciparum dihydroorotate dehydrogenase; hDHODH; human dihydroorotate dehydrogenase; FAD
Respiratory supercomplexes and the functional segmentation of the CoQ pool
Keywords: BN-PAGE; blue native polyacrylamide gel electrophoresis; CI to CV; complex I to complex V; CoQ; coenzyme Q; cyt c; cytochrome c; DHODH; dihydroorotate dehydrogenase; G3PDH; glycerol-3-phosphate dehydrogenase; IMM; inner mitochondrial membrane; LOM; loss o
Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH
Keywords: Poly (ADP-ribose) polymerase; PARP; PARP-1; Dihydroorotate dehydrogenase; DHODH; Benzimidazole;
Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline
Keywords: AD; Alzheimer's disease; BPP; Boerge Prien's Proeve; CAMB; Copenhagen Aging and Midlife Biobank; DHODH; dihydroorotate dehydrogenase; I-S-T; Intelligenz-Struktur-Test; MCI; mild cognitive impairment; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; PBMC; Peri
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
Keywords: 6PGD; 6-phosphogluconate dehydrogenase; 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; ADP; adenosine diphosphate; ADSCs; adipose-derived stem cells; aP2; fatty-acid binding protein; AREs; antioxidant response elements; ATP; adenosine tri
Crystal structure of dihydroorotate dehydrogenase from Leishmania major
Keywords: Leishmania major; Dihydroorotate dehydrogenase; Crystal structure; Orotate binding; Fumarate binding; Dimeric interface; NTDs; Neglected Tropical Diseases; DHODH; dihydroorotate dehydrogenase; LmDHODH; Leishmania major dihydroorotate dehydrogenase; LmDHOD
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection
Keywords: bsd; blasticidin S deaminase; DHFR; dihydrofolate reductase; DHODH; dihydroorotate dehydrogenase; DSM1; 5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)naphthalen-2-ylamine; DSM74; 5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)(4-trifluoromethylphenyl)amine;
Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies
Keywords: DHODH; dihydroorotate dehydrogenase; QD; 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone; Cell fractionation; Mitochondria; Malaria; Hemozoin; Magnetic separation; Spectrophotometric enzyme assay;
Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis
Keywords: 4HPR; N-(4-hydroxyphenyl)retinamide; BQR; brequinar; DCF; 2â²,7â²-dichlorofluorescein; DHODH; dihydroorotate dehydrogenase; EST; expressed sequence tag; F.U.; fluorescence unit; KGM; keratinocyte growth medium; KRB; Krebs-Ringer buffer; LFN; leflunomi
Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778
Keywords: Arava; Leflunomide; A771726; DHODH; EGF receptor;
Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes
Keywords: Human synoviocytes; Interleukin-10; Interleukin-11; Leflunomide; MAPK; COX; cyclooxygenase; DHODH; dihydroorotate deshydrogenase; DMARDs; disease modifying antirheumatic drugs; DMEM; Dulbecco's modified Eagle's medium; ELISA; enzyme-linked immunosorbent a