Keywords: دی هیدرووراتا د هیدروژناز; Dihydroorotate dehydrogenase; Leishmania major; Neglected diseases; Sesquiterpene lactones; Quantitative structure-activity relationships; Asteraceae;
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Keywords: دی هیدرووراتا د هیدروژناز; Dihydroorotate dehydrogenase; DHODH; Plasmodium falciparum; Inhibitor;
Keywords: دی هیدرووراتا د هیدروژناز; CtpS; cytidine 5â²-triphosphate synthetase (synthase); IMP; inosine monophosphate; IMPDH; inosine monophosphate dehydrogenase; ERES; endoplasmic reticulum exit sites; STORM; stochastic optical reconstruction microscopy; PRPP; phosphoribosyl pyrophosphate
Keywords: دی هیدرووراتا د هیدروژناز; Dihydroorotate dehydrogenase; Flavoenzyme; Pyrimidine biosynthesis; Drug target;
Keywords: دی هیدرووراتا د هیدروژناز; Hydralazines; Antimalarials; Dihydroorotate dehydrogenase; P. falciparum; Bronsted acidic ionic liquids
Keywords: دی هیدرووراتا د هیدروژناز; ACIII; Alternative Complex III; ADH; Alcohol dehydrogenase; ALDH; Aldehyde dehydrogenase; AMO; Ammonia monooxygenase; AOX; Alternative oxidase; CISM; Complex Iron-Sulfur Molybdoenzyme; DAADH; d-amino acid dehydrogenase; DHODH; dihydroorotate dehydrogenase
Keywords: دی هیدرووراتا د هیدروژناز; I; complex I; II; complex II; III; complex III; IV; complex IV; α-KGDH; α-ketoglutarate dehydrogenase; AO; alternative oxidase; cyt; cytochrome; DHODH; dihydroorotate dehydrogenase; ETF; electron transfer flavoprotein; GLRX; glutaredoxin; GPx; glutathio
Keywords: دی هیدرووراتا د هیدروژناز; Leishmaniosis; Leishmania amazonensis; Trypanosomatids; Metabolic pathway enzymes inhibitors; Dihydroorotate dehydrogenase
Keywords: دی هیدرووراتا د هیدروژناز; Pyrimidine metabolism; Pathogens; CAD; Dihydroorotase; Dihydroorotate dehydrogenase; UMP synthase; CAD; multifunctional protein that initiates and regulates de novo pyrimidine biosynthesis; DHODase; dihydroorotate dehydrogenase; hpi; hours post infection;
Keywords: دی هیدرووراتا د هیدروژناز; Drug development; Translational research; Inflammatory bowel disease; Colitis; Biomarkers; Endpoints; AA; alternative approaches; CD; Crohn's disease; 3Rs; Replacement, Reduction, Refinement; DHODH; dihydroorotate dehydrogenase; DNBS; dinitrobenzene sulph
Optimizing conventional DMARD therapy for Sjögren's syndrome
Keywords: دی هیدرووراتا د هیدروژناز; 6-MP; 6-mercaptopurine; 6-T-GTP; 6-thioguanine triphosphate; ABT; abatacept; Ach; acetylcholine; ALAT; alanine amino transferase; AZA; azathioprine; BAFF; B cell activating factor; Bcl-6; B cell lymphoma 6; bDMARDs; biological disease modifying antirheuma
Full length articleEffects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro
Keywords: دی هیدرووراتا د هیدروژناز; Theileria equi; Babesia caballi; Equine piroplasmosis; Atovaquone; Dihydroorotate dehydrogenase;
Multicomplex-based pharmacophore modeling coupled with molecular dynamics simulations: An efficient strategy for the identification of novel inhibitors of PfDHODH
Keywords: دی هیدرووراتا د هیدروژناز; Malaria; Dihydroorotate dehydrogenase; Pharmacophore; Docking; Drug-likeness; Molecular dynamics;
Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells
Keywords: دی هیدرووراتا د هیدروژناز; ATP; Breast cancer; Dihydroorotate dehydrogenase; Normal cells and reactive oxygen species production; ATP; Adenosine triphosphate; ROS; Reactive oxygen species; DHODH; Dihydroorotate dehydrogenase; LFM; Leflunomide; BQR; Brequinar sodium; DMSO; Dimethyl
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials
Keywords: دی هیدرووراتا د هیدروژناز; Malaria; Dihydroorotate dehydrogenase (DHODH); Pyrimidine biosynthesis; Plasmodium parasite; Drug resistance; DHODH; dihydroorotate dehydrogenase; PfDHODH; Plasmodium falciparum dihydroorotate dehydrogenase; hDHODH; human dihydroorotate dehydrogenase; FAD
Respiratory supercomplexes and the functional segmentation of the CoQ pool
Keywords: دی هیدرووراتا د هیدروژناز; BN-PAGE; blue native polyacrylamide gel electrophoresis; CI to CV; complex I to complex V; CoQ; coenzyme Q; cyt c; cytochrome c; DHODH; dihydroorotate dehydrogenase; G3PDH; glycerol-3-phosphate dehydrogenase; IMM; inner mitochondrial membrane; LOM; loss o
Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage
Keywords: دی هیدرووراتا د هیدروژناز; ART; artemisinin; DCF; dichlorofluorescein; DCFH; 2â²,7â²-dichlorodihydrofluorescein; DHOD; dihydroorotate dehydrogenase; DNPH; dinitrophenylhydrazine; FP IX; ferritoprotoporphyrin IX; FTC; fluorescein 5-thiosemicarbazide; GR; glutathione reductase; Grx
Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH
Keywords: دی هیدرووراتا د هیدروژناز; Poly (ADP-ribose) polymerase; PARP; PARP-1; Dihydroorotate dehydrogenase; DHODH; Benzimidazole;
Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline
Keywords: دی هیدرووراتا د هیدروژناز; AD; Alzheimer's disease; BPP; Boerge Prien's Proeve; CAMB; Copenhagen Aging and Midlife Biobank; DHODH; dihydroorotate dehydrogenase; I-S-T; Intelligenz-Struktur-Test; MCI; mild cognitive impairment; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; PBMC; Peri
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
Keywords: دی هیدرووراتا د هیدروژناز; 6PGD; 6-phosphogluconate dehydrogenase; 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; ADP; adenosine diphosphate; ADSCs; adipose-derived stem cells; aP2; fatty-acid binding protein; AREs; antioxidant response elements; ATP; adenosine tri
Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm
Keywords: دی هیدرووراتا د هیدروژناز; CPSII; carbamoyl-phosphate synthetase II; LIT; liver infusion tryptose; DHOD; dihydroorotate dehydrogenase; MOI; a multiplicity of infection; Trypanosoma cruzi; Pyrimidine biosynthesis pathway; Carbamoyl-phosphate synthetase II; Gene targeting; Cell growt
Leflunomide in dermatology
Keywords: دی هیدرووراتا د هیدروژناز; atopic dermatitis; dihydroorotate dehydrogenase; leflunomide; psoriasis; psoriatic arthritis; rheumatoid arthritis; tumor necrosis factor-alfa
Crystal structure of dihydroorotate dehydrogenase from Leishmania major
Keywords: دی هیدرووراتا د هیدروژناز; Leishmania major; Dihydroorotate dehydrogenase; Crystal structure; Orotate binding; Fumarate binding; Dimeric interface; NTDs; Neglected Tropical Diseases; DHODH; dihydroorotate dehydrogenase; LmDHODH; Leishmania major dihydroorotate dehydrogenase; LmDHOD
Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii
Keywords: دی هیدرووراتا د هیدروژناز; DAPI; 4â²,6-diamino-2-phenylindole; EDTA; ethylenediaminetetraacetic acid; PBS; phosphate buffered saline; PMSF; phenylmethanesulfonyl fluoride; PVDF; polyvinylidene difluoride; Dihydroorotate dehydrogenase; Pyrimidine biosynthesis; Toxoplasma gondii; Mi
Transcript Level Responses of Plasmodium falciparum to Antimycin A
Keywords: دی هیدرووراتا د هیدروژناز; DHOD; dihydroorotate dehydrogenase; IMM; inner mitochondrial membrane; LD; lethal dose; mtETC; mitochondrial electron transport chain; qRT-PCR; quantitative reverse transcription polymerase chain reaction; Plasmodium; mitochondria; antimycin A; retrograde
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection
Keywords: دی هیدرووراتا د هیدروژناز; bsd; blasticidin S deaminase; DHFR; dihydrofolate reductase; DHODH; dihydroorotate dehydrogenase; DSM1; 5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)naphthalen-2-ylamine; DSM74; 5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)(4-trifluoromethylphenyl)amine;
Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension
Keywords: دی هیدرووراتا د هیدروژناز; Dihydroorotate dehydrogenase; Membrane association; Electron spin resonance; Vesicles; Site directed spin labeling;
Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies
Keywords: دی هیدرووراتا د هیدروژناز; DHODH; dihydroorotate dehydrogenase; QD; 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone; Cell fractionation; Mitochondria; Malaria; Hemozoin; Magnetic separation; Spectrophotometric enzyme assay;
Microarray analysis of Leflunomide-induced limb malformations in CD-1 mice
Keywords: دی هیدرووراتا د هیدروژناز; Dihydroorotate dehydrogenase; Leflunomide; Limb deformity; Microarray; Tyrosine kinase
Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis
Keywords: دی هیدرووراتا د هیدروژناز; 4HPR; N-(4-hydroxyphenyl)retinamide; BQR; brequinar; DCF; 2â²,7â²-dichlorofluorescein; DHODH; dihydroorotate dehydrogenase; EST; expressed sequence tag; F.U.; fluorescence unit; KGM; keratinocyte growth medium; KRB; Krebs-Ringer buffer; LFN; leflunomi
Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion
Keywords: دی هیدرووراتا د هیدروژناز; ETC; electron transport chain; Pf; Plasmodium falciparum; PPO; protoporphyrinogen oxidase; CPO; coproporphyrinogen oxidase; LDH; lactate dehydrogenase; SQR; succinate-ubiquinone reductase; QFR; quinol-fumarate reductase; DHOD; dihydroorotate dehydrogenase
Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry
Keywords: دی هیدرووراتا د هیدروژناز; Chagas disease; Trypanosoma cruzi; Dihydroorotate dehydrogenase; Enzyme kinetics; Activation thermodynamic parameters
Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials
Keywords: دی هیدرووراتا د هیدروژناز; QSAR; Docking; Antimalarials; Dihydroorotate dehydrogenase; Validation
Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors
Keywords: دی هیدرووراتا د هیدروژناز; Type II NADH dehydrogenase; NDH2; Dibenziodolium chloride; DPI; Diphenyliodonium chloride; IDP; 1-Hydroxy-2-dodecyl-4(1H)quinolone; HDQ; Dihydroorotate dehydrogenase; DHOD; Ubiquinone; CoQ; CoQn
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain
Keywords: دی هیدرووراتا د هیدروژناز; Trypanosoma cruzi; Y strain; Dihydroorotate dehydrogenase; Cloning; Expression; Purification; Crystallization; X-ray crystallography
Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms
Keywords: دی هیدرووراتا د هیدروژناز; DHOD; dihydroorotate dehydrogenase; ACT; aspartate carbamoyltransferase; pyr; de novo pyrimidine biosynthetic gene; Trypanosoma cruzi; Dihydroorotate dehydrogenase; Pyrimidine-biosynthetic gene cluster; Genetic diversity; Drug target;
Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase
Keywords: دی هیدرووراتا د هیدروژناز; Leishmania major Friedlin; Dihydroorotate dehydrogenase; Cloning; Expression; Purification; Steady-state kinetics; Ping-Pong mechanism
Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells
Keywords: دی هیدرووراتا د هیدروژناز; Trypanosoma cruzi; De novo pyrimidine biosynthesis; Dihydroorotate dehydrogenase; Marine algae extracts;