کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5591512 | 1404978 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Higher order structures in purine and pyrimidine metabolism
ترجمه فارسی عنوان
ساختار نظم بالاتر در متابولیسم پورین و پیریمیدین
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کلمات کلیدی
Orotate phosphoribosyl transferasemTORC1IMPDHinosine monophosphate dehydrogenaseTBCASAICARadenylosuccinate lyaseTBBglycinamide ribonucleotideTBIDHODEndoplasmic reticulum exit sitesCPS-IIPRPPPPATuridine monophosphateUMPSDHOOMPDCtetrabromocinnamic aciddmaTAICARASLMesoscale structuresmTORHSP90ACTCTPSCK2hsp70UMPEREsGPCRIMPGARG-protein coupled receptor - G-پروتئین همراه گیرندهmTOR complex 1 - mTOR پیچیده 1AIRS - ایرسGARS - بچه هاOPRT - جرثقیلdihydroorotate dehydrogenase - دی هیدرووراتا د هیدروژنازDihydroorotase - دی هیدروورتازCAIR - سقوطCTP synthetase - سنتتاز CTPCAD - طراحی به کمک رایانه یا کَدstorm - طوفانphosphoribosyl pyrophosphate - فسفریبوسیل پیرو فسفاتPurine metabolism - متابولیسم پورینPyrimidine metabolism - متابولیسم پیریمیدینMacromolecular assembly - مجمع بزرگInosine monophosphate - مونوفسفات inosinestochastic optical reconstruction microscopy - میکروسکوپ بازسازی نوری تصادفیmammalian target of rapamycin - هدف پستانداران رپامایسینAIR - هواheat shock protein 70 - پروتئین شوک حرارت 70Heat shock protein 90 - پروتئین شوک حرارت 90Aspartate carbamoyltransferase - کاربامویل ترانسفراز آسپارتاتCarbamoyl phosphate synthetase - کارباموییل فسفات سنتتازCasein kinase 2 - کازئین کیناز 2GART - گارت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
چکیده انگلیسی
The recent discovery of several forms of higher order protein structures in cells has shifted the paradigm of how we think about protein organization and metabolic regulation. These dynamic and controllable protein assemblies, which are composed of dozens or hundreds of copies of an enzyme or related enzymes, have emerged as important players in myriad cellular processes. We are only beginning to appreciate the breadth of function of these types of macromolecular assemblies. These higher order structures, which can be assembled in response to varied cellular stimuli including changing metabolite concentrations or signaling cascades, give the cell the capacity to modulate levels of biomolecules both temporally and spatially. This provides an added level of control with distinct kinetics and unique features that can be harnessed as a subtle, yet powerful regulatory mechanism. Due, in large part, to advances in structural methods, such as crystallography and cryo-electron microscopy, and the advent of super-resolution microscopy techniques, a rapidly increasing number of these higher order structures are being identified and characterized. In this review, we detail what is known about the structure, function and control mechanisms of these mesoscale protein assemblies, with a particular focus on those involved in purine and pyrimidine metabolism. These structures have important implications both for our understanding of fundamental cellular processes and as fertile ground for new targets for drug discovery and development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 197, Issue 3, March 2017, Pages 354-364
Journal: Journal of Structural Biology - Volume 197, Issue 3, March 2017, Pages 354-364
نویسندگان
Iva Chitrakar, Deborah M. Kim-Holzapfel, Weijie Zhou, Jarrod B. French,