Keywords: AT; adipose tissue; BM; bone marrow; CsA; cyclosporine A; COX-2; cyclooxygenase-2; DEX; dexamethasone; DMEM; Dulbeccós modified Eaglés medium; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorbent assay; FasL; Fas ligand; HGF; hepatocyte growth f
مقالات ISI (ترجمه نشده)
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Keywords: CtpS; cytidine 5â²-triphosphate synthetase (synthase); IMP; inosine monophosphate; IMPDH; inosine monophosphate dehydrogenase; ERES; endoplasmic reticulum exit sites; STORM; stochastic optical reconstruction microscopy; PRPP; phosphoribosyl pyrophosphate
Keywords: MZR; mizoribine; MMF; mycophenolate mofetil; RCTs; randomized controlled trials; CMV; cytomegalovirus; HZV; Herpes zoster virus; BKV; Polyomavirus BK; CNIs; calcineurin inhibitors; AZA; azathioprine; CsA; cyclosporine; ITT; intention-to-treat; IMPDH; inos
Hit discovery of Mycobacterium tuberculosis inosine 5â²-monophosphate dehydrogenase, GuaB2, inhibitors
Keywords: Tuberculosis; Anti-tubercular; IMPDH; 1,2,3-Triazole; Mycobacterium tuberculosis; GuaB2;
Optimization and application of an HPLC method for quantification of inosine-5â²-monophosphate dehydrogenase activity as a pharmacodynamic biomarker of mycophenolic acid in Chinese renal transplant patients
Keywords: Mycophenolic acid; Inosine 5â²-monophosphate dehydrogenase; High performance liquid chromatography; Pharmacodynamic biomarker; AEC; area under enzyme activity-time curve; AMP; adenosine monophosphate; AUC; area under the concentration-time curve; BSA; bo
Inosine Monophosphate Dehydrogenase Pharmacogenetics in Hematopoietic Cell Transplantation Patients
Keywords: Hematopoietic cell transplant; Pharmacogenomics; IMPDH; MPA; Precision medicine; Graft-versus-host disease;
ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase
Keywords: ASB; ankyrin repeat and SOCS box-containing; co-IP; co-immunoprecipitate; CRL; cullin-RING ubiquitin ligase; DMEM; Dulbecco's Modified Eagle's Medium; IMPDH; inosine monophosphate dehydrogenase; MS; mass spectrometry; SNP; single-nucleotide polymorphism;
Discovery of novel human inosine 5â²-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents
Keywords: IMPDH; hIMPDH2 inhibitors; 5-Aminoisobenzofuran-1(3H)-one; MTT assay; Anticancer agents;
Research paperPreclinical activity of FF-10501-01, a novel inosine-5â²-monophosphate dehydrogenase inhibitor, in acute myeloid leukemia
Keywords: Acute myeloid leukemia; IMPDH; HMA resistance; Guanosine; Metabolic inhibitor;
Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients
Keywords: ALL; Acute childhood leukemia; 6-MP or MP; 6-mercaptopurine; AZA; azathioprine; IBD; inflammatory bowel disease; MeMP; methylmercaptopurine; MeMP-d3; Methymercaptopurine-D3; TIMP; thioinosine monophosphate; TIDP; thioinosine diphosphate; TITP; thioinosine
ReviewIdeal oral combinations to eradicate HCV: The role of ribavirin
Keywords: HCV; hepatitis C virus; SVR; sustained virological response; RBV; ribavirin; IFN; interferon; Peg-IFN; pegylated interferon; DAA; direct-acting antiviral; ALT; alanine transaminase; GTP; guanosine triphosphate; IMPDH; inosine monophosphate dehydrogenase;
GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites
Keywords: HGPRT; hypoxanthine-xanthine phosphoribosyltransferase; XPRT; xanthine phosphoribosyltransferase; dCF; 2â²-deoxycoformycin; ADSS; adenylosuccinate synthetase; ASL; adenylosuccinate lyase; IMPDH; IMP dehydrogenase; GMPR; GMP reductase; CBS; cystathionine-
A putative role for inosine 5â² monophosphate dehydrogenase (IMPDH) in Leishmania amazonensis programmed cell death
Keywords: Leishmania amazonensis; IMPDH; Ribavirin; Mycophenolic acid (MPA); Apoptosis-like programmed cell death;
Target validation of the inosine monophosphate dehydrogenase (IMPDH) gene in Cryptosporidium using Phylomer® peptides
Keywords: Cryptosporidium; Drug target validation; Peptide; Phylomer®; Inosine 5'-monophosphate dehydrogenase; IMPDH
Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus
Keywords: Cell Culture Model; Liver Disease; Immunity; Transplantation; CsA; cyclosporin A; CypA/B; cyclophilin A/B; Dex; dexamethasone; HCV; hepatitis C virus; HEV; hepatitis E virus; IMPDH; inosine monophosphate dehydrogenase; MPA; mycophenolic acid; Pred; predni
Xanthosine administration does not affect the proportion of epithelial stem cells in bovine mammary tissue, but has a latent negative effect on cell proliferation
Keywords: LREC, label-retaining epithelial cellStem cell; Mammary gland; Bovine; Xanthosine; IMPDH
Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum
Keywords: IMPDH; IMP dehydrogenase; Cryptosporidiosis; Antiparasitic
Variability of Apoptosis and Response in N1-S1 Rodent Hepatomas to Benzamide Riboside and Correlation to Early Changes in Water Apparent Diffusion Coefficient and Sodium MR Imaging
Keywords: ADC; apparent diffusion coefficient; BR; benzamide riboside; HCC; hepatocellular carcinoma; IA; intraarterial; IMPDH; inosine monophosphate dehydrogenase; NAD; nicotinamide adenine dinucleotide; SI; signal intensity; SQ; single-quantum; TQF; triple-quantu
Cloning, characterization and validation of inosine 5′-monophosphate dehydrogenase of Babesia gibsoni as molecular drug target
Keywords: Babesia; IMPDH; Mycophenolic acid
Mizoribine-An inosine monophosphate dehydrogenase inhibitor-acts synergistically with cyclosporine A in prolonging survival of murine islet cell and heart transplants across major histocompatibility barrier
Keywords: MZR; Mizoribine; MMF; Mycophenolate mofetil; CsA; Cyclosporine; IMPDH; Inosine monophosphate dehydrogenase; NFGB; Non-fasting blood glucose; Mizoribine; Cyclosporine; Immunosuppression; Murine heterotopic heart transplantation; Murine islet transplantatio
A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH
Keywords: p53; miR-34a; IMPDH; Ras; Purine metabolism
Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations
Keywords: 1,2,4-Triazole; Imidazole; l-ascorbic acid; Anti-HCV activity; Antitumor activity; IMPDH;
Effects of 3-Hydrogenkwadaphnin on intracellular purine nucleotide contents and their link to K562 cell death
Keywords: 3-HK; 3-Hydrogenkwadaphnin; AdSS; adenylosuccinate synthetase; Guo; guanosine; HPLC; high performance liquid chromatography; IMPDH; inosine 5â²- monophosphate dehydrogenase; Apoptosis; 3-Hydrogenkwadaphnin; HPLC; Nucleotide contents; K562 cells;
Mechanism of action of ribavirin in a novel hepatitis C virus replication cell system
Keywords: HCV; hepatitis C virus; E1; envelope 1; NS2; nonstructural protein 2; PEG; polyethylene glycol; IFN; interferon; RBV; ribavirin; SVR; sustained virological response; IMPDH; inosine monophosphate dehydrogenase; RL; renilla luciferase; EC50; 50% effective c
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain
Keywords: AMP; adenosine 5â²-monophosphate; IMP; inosine 5â²-monophosphate; IMPDH; inosine monophosphate dehydrogenase; NAD; nicotinamide adenine dinucleotide; NMN; nicotinamide mononucleotide; TR; tiazofurin; TAD; thiazole-4-carboxamide adenine dinucleotide; MPA
Mycophenolic acid and intravenous immunoglobulin exert an additive effect on cell proliferation and apoptosis in the mixed lymphocyte reaction
Keywords: CNI; Calcineurin inhibitor; DGF; Delayed graft function; IMPDH; Inosinemonophosphatedehydrogenase; IVIG; Intravenous immunoglobulin; MDK; Marginal donor kidneys; MMF; Mycophenolatemofetil; MPA; Mycophenolic acid; PBLs; Peripheral blood leucocytes; PBMCs;
Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats
Keywords: IMPDH; BMS-566419; MMF; UUO; Renal fibrosis; Collagen; MCP-1; TGF-β1
Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection
Keywords: IMPDH; BMS-566419; MMF; Allograft rejection; Antibody production
Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity
Keywords: IMPDH; Adipocyte; Guanine nucleotides; Obesity
Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption
Keywords: IMPDH; RNA polymerase I; AVN-944; GTP depletion; Nucleolar protein; Ribosomal RNA
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor
Keywords: Inosine monophosphate dehydrogenase; IMPDH; NAD analogue; Pyrophosphate mimics; Methylenebis(sulfonamide)
Mycophenolic acid as a latent agonist of PPARγ
Keywords: Mycophenolic acid; IMPDH; PPARγ; 3T3-L1; Inhibitor; SPR
Modulation of host metabolism as a target of new antivirals
Keywords: HCV; hepatitis C virus; CH; chronic hepatitis; HCC; hepatocellular carcinoma; IFN; interferon; SVR; sustained virological response; PEG-IFN; pegylated-IFN; GBV-B; GB virus B; uPA-SCID; urokinase plasminogen activator-severe combined immunodeficiency; NS;
Novel indole inhibitors of IMPDH from fragments: Synthesis and initial structure–activity relationships
Keywords: IMPDH; Inosine monophosphate dehydrogenase; Fragment elaboration
Low molecular weight indole fragments as IMPDH inhibitors
Keywords: IMPDH; Inosine monophosphate dehydrogenase; Fragment
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH
Keywords: IMPDH; Immunosuppression; Transplant; Mycophenolic acid; Phosphonic acid; Enzyme inhibitor
Inosine 5′-monophosphate dehydrogenase inhibition by mycophenolic acid impairs maturation and function of dendritic cells
Keywords: Dendritic cells; Mycophenolic acid; Immunosuppression; IMPDH; GTP
Cancers et immunosuppression : effet pro- et antitumoral des traitements immunosuppresseurs
Keywords: Cancer; Immunosuppresseurs; Carcinogenèse; Transplantation d'organe; Inhibiteurs de la calcineurine; Inhibiteurs de la protéine mTOR; Cancer; Immunosuppressive drugs; Carcinogenesis; Organ transplantation; Calcineurin inhibitors; mTOR inhibitors; LPT; L
The 5â²-nucleotidases as regulators of nucleotide and drug metabolism
Keywords: 2,3-BPG; 2,3-bisphosphoglycerate; 3TCMP; 2â²-deoxy-3â²-thiacytidine monophosphate; 5-EddU; 5-ethynyl-dideoxyuridine; 5â²-NT; 5â²-nucleotidase; ADA; adenosine deaminase; AK; adenosine kinase; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukem