Effects of 3-Hydrogenkwadaphnin on intracellular purine nucleotide contents and their link to K562 cell death

► 3-HK depletes GTP/ATP pool sizes. ► Inhibition of intracellular AdSS activity by 3-HK. ► Guanosine reverses the effects of 3-HK on ATP/GTP pool sizes. ► 3-HK exerts its anti-proliferative effect through depletion of purine nucleotides.