Keywords: CYP; AAP; 4-aminophenazone; ALP; alkaline phphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CAT; catalase; CYPs; cytochrome P 450s; DHBS; 3,5-Dichloro -2-hydroxybenzene sulfonic acid; EDTA; ethylenediaminetetraacetic acid; GGT; gamma g
مقالات ISI CYP (ترجمه نشده)
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Keywords: CYP; NAFLD; non-alcoholic fatty liver disease; NAFL; non-alcoholic fatty liver; NASH; non-alcoholic steatohepatitis; mtDNA; mitochondrial DNA; FFAs; free fatty acids; TNF; tumor necrosis factor; CTRL; control; HF; high-fat; HF+HCh; high-fat+high-cholesterol; 7
Keywords: CYP; Carcinogenesis; Chemoprevention; Chemotherapy; Oxidative stress; Nrf2; Phytochemicals; AKT; protein kinase B; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ATF-2; activating transcriptional factor; BBN; N-butyl-N-(4-hydroxybutyl)n
Keywords: CYP; Comet assay; DNA repair capability; Metabolites; Photosensitized DNA damage; Phototoxicity; DCF; diclofenac; 5OH-DCF; 5-hydroxy-diclofenac; 4â²OH-DCF; 4â²-hydroxy-diclofenac; CPZ; chlorpromazine; SDS; sodium dodecyl sulphate; NSAID; nonsteroidal antiinf
Keywords: CYP; 4-ABP; 4-aminobiphenyl; CI; confidence interval; CrI; credible interval; AA-Hb; acrylamide-hemoglobin; AcE; acetylcholinesterase; AhR; aryl hydrocarbon receptor; APFO; ammonium perfluorooctanoate; AR; androgen receptor; BBMP; 2,2-bis(bromomethyl)-1,3-prop
Keywords: CYP; BTZ; bortezomib; CFZ; carfilzomib; C-L; caspase-like; CNS; central nervous system; CT-L; chymotrypsin-like; CYPs; cytochrome P450 enzymes; iP; immunoproteasome; IXZ; ixazomib; MM; multiple myeloma; OPZ; oprozomib; PD; pharmacodynamic; PI; proteasome inhib
Keywords: CYP; Bayesian analysis; Glutathione conjugation; Oxidative metabolism; Tetrachloroethylene; Physiologically based pharmacokinetic (PBPK) model; Risk assessment; CC; Collaborative Cross; CDC; Centers for Disease Control and Prevention; CU; coefficient of uncert
Keywords: CYP; Methionine; Metovitan; Anti-tuberculosis drugs; CYPs; Spermatogenesis; Testes;
Keywords: CYP; Clementine; CYPs; Drug transporters; Grapefruit; Mandarin; HPLC-DAD-ESI-MS-MS;
Keywords: CYP; ALA; 5-aminolevulinic acid; AMT; Adsorptive-mediated transcytosis; BBB; Blood-brain barrier; B-CSF; Blood-cerebrospinal fluid barrier; CNS; Central nervous system; CSF; Cerebrospinal fluid; CYPs; Cytochromes P450; FUS; Focused ultrasound; GLUT-1; Glucose
Metabolic profiling of five flavonoids from Dragon's Blood in human liver microsomes using high-performance liquid chromatography coupled with high resolution mass spectrometry
Keywords: CYP; CYPs; cytochrome P450s; DB; Dragon's Blood; HLMs; human liver microsomes; HPLC-HR-MS; high performance liquid chromatography coupled with high resolution mass spectrometry; tR; retention time; Dragon's Blood; Human liver microsomes; HPLC-HR-MS; Metabolite
Keywords: CYP; Cyps; cyclophilins; CypA; cyclophilin A; PPIases; peptidyl-prolyl isomerases; CsA; cyclosporin A; HIV-1; human immunodeficiency virus 1; HCV; hepatitis C virus; SBDD; structure-based drug design; FBDD; fragment-based drug discovery; MD; molecular dynami
Keywords: CYP; ASTRO; astroglial brain tumors; CBT; childhood brain tumor; CNS; central nervous system; CYPs; cytochrome P450s; 95% CI; 95% confidence interval; 2,4-D; 2,4-dichlorophenoxy acetic acid; ICCC; international classification of children cancer; ICD; internati
Keywords: CYP; Hydrogen peroxide activation; Metal complexes; Photosensitizers; Semiconductors; Redox reactions; Photocatalysis; ROS; reactive oxygen species; SOD; superoxide dismutase; Por; porphyrin; TAML; tetraamido macrocyclic ligand; DFT; density functional theory;
Keywords: CYP; DP; Dechlorane Plus; e-waste; electronic waste; GT; the great tit (Parus major); OMR; the oriental magpie-robin (Copsychus saularis); LVB; the light-vented bulbul (Pycnonotus sinensis); RWB; the red-whiskered bulbul (Pycnonotus jocosus); SBSB; the streak-
Keywords: CYP; MMP; mitochondrial membrane potential; H2DCF-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; CYPs; cytochrome P450; Antioxidants; Resveratrol; Endothelial cells; Pro-oxidant effect; Cell damage;
Keywords: CYP; Alas1; aminolevulinic acid synthase 1; ALT; alanine aminotransferase; APAP; acetaminophen; Arntl; aryl hydrocarbon receptor nuclear translocator-like; Arrdc3; arrestin domain containing 3; AST; aspartate aminotransferase; Atp2b2; ATPase calcium transporti
Keywords: CYP; Atlantic cod; Dissolved CO2; PFOS; Endocrine effects; Sex hormones; CYPs
A CYP2B6-humanized mouse model and its potential applications
Keywords: CYP; CYP2B6; Liver; Drug metabolism; Xenobiotic toxicity; Knockout mice; Humanized mice; WT; wild-type; CYPs; cytochromes P450; CAR; constitutive androstane receptor; PXR; pregnane X receptor; GR; glucocorticoid receptor; PB; phenobarbital; and DEX; dexamethas
Herb-drug interaction of Nisha Amalaki and Curcuminoids with metformin in normal and diabetic condition: A disease system approach
Keywords: CYP; NA; Nisha Amalaki; CE; Curcuminoids; MET; metformin; DDI; drug-drug interactions; HDI; herb-drug interactions; CYPs; cytochrome p450 isoenzymes; IS; internal standard; MWR; Male Wistar rats; STZ; streptozotocin; MNC; mononuclear cells; OCT; organic cation
UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro
Keywords: CYP; Morusin; Glucuronidation; First-pass metabolism; Pharmacokinetics; UGTs; CYPs;
Diverse responses of tanshinone biosynthesis to biotic and abiotic elicitors in hairy root cultures of Salvia miltiorrhiza and Salvia castanea Diels f. tomentosa
Keywords: CYP; AACT; acetyl-CoA C-acetyltransferase; CPS; copalyl diphosphate synthase; CT; cryptotanshinone; CYPs; cytochromes P450; DMAPP; dimethylallyl diphosphate; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulo
MS methods to study macromolecule-ligand interaction: Applications in drug discovery
Keywords: CYP; MS; mass spectrometry; IM-MS; ion mobility mass spectrometry; HR-MS; high resolution mass spectrometry; MS/MS; tandem mass spectrometry; ESI; electrospray ionization; NSI; nanoelectrospray ionization; MALDI; matrix assisted laser desorption ionization; FT
Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib
Keywords: CYP; CA; caffeic acid; CT; cryptotanshinone; CYP76AH1; cytochrome P450 dependent monooxygenase; CYPs; cytochromes P450; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DW; dry weigh
4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells
Keywords: CYP; PAIB-SOs; phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates; CYPs; cytochromes P450; PAIB-SAs; 4-(3-alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides; PIB-SOs; phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates; PIB-SAs; phenyl 4-(2-oxoim
Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects
Keywords: CYP; CYPs; cytochrome P450s; HDIs; herb-drug interactions; HLMs; human liver microsomes; NADPï¼; β-nicotinamide adenine dinucleotide phosphate; QSAR; quantitative structure activity relationship; CoMFA; comparative molecular field analysis; LC-MS; liquid c
Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2
Keywords: CYP; Cytochrome P450; Inhibitory effects; Danshen; CYP2C8; CYP2J2; Herb-drug interactions; AA; arachidonic acid; CA; caffeic acid; Cry; cryptotanshinone; CYPs; Cytochrome P450 enzymes; DSS; danshensu; DI; dihydrotanshinone I; EETs; epoxyeicosatrienoic acids; F
Effects of diosmetin on nine cytochrome P450 isoforms, UGTs and three drug transporters in vitro
Keywords: CYP; Diosmetin; Cytochrome P450; UDP-glucuronyltransferases; Hepatic uptake transporters; Drug-drug interactions; CYPs; Cytochrome P450 enzymes; DDI; drug-drug interactions; HDI; herb-drug interactions; HLMs; human liver microsomes; NTCP; Na+-taurocholate cotr
Enzymatic mechanisms and detoxification of dry olive-mill residue by Cyclocybe aegerita, Mycetinis alliaceus and Chondrostereum purpureum
Keywords: CYP; Class II peroxidases; Laccase; Olive-mill residues; Unspecific peroxygenase; CYPs; Phytotoxicity;
Original articleInfluence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy
Keywords: CYP; Refractory epilepsy; CYPs; SNPs; Anticonvulsant drugs;
Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis
Keywords: CYP; Syl930; Hydroxylated metabolites; CYP450 isoforms; Metabolism; LC-MS/MS; CYPs; cytochrome P450 isoforms; LM; liver microsome; HLM; human liver microsome; RLM; rat liver microsome; MS; multiple sclerosis; S1PRs; sphingosine-1-phosphate receptors; S1PR1; sp
Nonmonotonic responses to low doses of xenoestrogens: A review
Keywords: CYP; AhR; aryl hydrocarbon receptor; AR; androgen receptor; BPA; bisphenol A; CYPs; cytochrome P450s; DES; diethylstilbestrol; DnBP; di-n-butyl phthalate; Dpf; days post-fertilization; Dph; days post-hatch; E2; 17β-estradiol; EE2; 17α-ethynylestradiol; EDCs;
Sestrin2 protects against acetaminophen-induced liver injury
Keywords: CYP; Sestrin2; Acetaminophen; Oxidative stress; JNK; Ad-LacZ; adenovirus which expressed LacZ; Ad-Sesn2; adenovirus which expressed Sesn2; ALD; alcoholic liver diseases; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CYPs;
In vitro inhibitory mechanisms and molecular docking of 1â²-S-1â²-acetoxychavicol acetate on human cytochrome P450 enzymes
Keywords: CYP; 1â²-S-1â²-acetoxychavicol acetate; Drug interaction; Cytochrome P450; Inhibition; Enzyme kinetics; Molecular docking; ACA; 1â²-s-1â²-acetoxychavicol acetate; BOMCC; 7-benzyloxymethyloxy-3-cyanocoumarin; CYPS; cytochrome p450s; DBOMF; dibenzyloxymethyl
Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine
Keywords: CYP; Experimental colitis; Dextran sulfate sodium; CYPs; Rat liver microsomes; Rat renal microsomes; Rat intestinal microsomes;
Prenatal exposure to drinking-water chlorination by-products, cytochrome P450 gene polymorphisms and small-for-gestational-age neonates
Keywords: CYP; BDCM; bromodichloromethane; CBPs; chlorination by-products; CYPs; cytochrome P450; DBPs; disinfection by-products; DCAA; dichloroacetic acid; HAAs; haloacetic acids; HAA5; five regulated haloacetic acids; IUGR; intra-uterine growth restriction; LD; linkag
Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes
Keywords: CYP; AhR; aryl hydrocarbon receptor; AMC; 7-amino-4-methylcoumarin; α-NF; alpha-naphthoflavone; ATM; ataxia telangiectasia mutated; B[a]P; benzo[a]pyrene; BPDE; B[a]P diol epoxide; CYPs; cytochromes P-450; DMSO; dimethyl sulfoxide; DDR; DNA damage response; D
Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review
Keywords: CYP; 2-AA; 2-aminoanthracene; Ach; Acetylcholine; AF2; 2-aminofluorene; Aq; Aqueous; BMI; Body mass index; BP; Blood pressure; BUN; Blood urea nitrogen; CYPs; Cytochromes P450; DBP; Diastolic blood pressure; DPPH; 2,2-diphenyl-1-picrylhydrazyl; ECG; Electrocar
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity
Keywords: CYP; MPS; microphysiological system; LDH; lactate dehydrogenase; ALT; alanine aminotransferase; BNF; beta-naphthoflavone; Rif; rifampin; EROD; ethoxyresorufin-O-deethylase; CYPs; cytochrome P450s; HNF4α; hepatocyte nuclear factor 4 alpha; MDZ; midazolam; AFB;
Structural aspects of Vitamin D endocrinology
Keywords: CYP; Vitamin D3; DBP; CYPs; VDR; HVDRR; Structure; Allostery;
Testosterone metabolism of equine single CYPs of the 3A subfamily compared to the human CYP3A4
Keywords: CYP; POR; NADPH P450 oxidoreductase; CYPs; cytochrome P450 enzymes; CYB5; cytochrome b5; Sf9; insect cells of Spodoptera frugiperda; HPLC; high-pressure liquid chromatography; NADPH; nicotinamide adenine dinucleotide phosphate; NDSB; non-detergent sulfobetaine
Insight into the contribution of isoprostanoids to the health effects of omega 3 PUFAs
Keywords: CYP; AA; arachidonic acid; ALA; α-linolenic acid; APCI; atmospheric pressure chemical ionization; ApoB100; apolipoprotein B100; BHT; butylated hydroxytoluene; BSTFA; bis-(trimethylsilyl)trifluoroacetamide; CCl4; tetrachloromethane; CNS; central nervous system
What is the contribution of human FMO3 in the N-oxygenation of selected therapeutic drugs and drugs of abuse?
Keywords: CYP; FMO3; CYPs; Drugs of abuse; Relative activity factor approach; Hepatic clearance;
Maintenance of in vivo induced cytochrome P-450s in hepatocyte monolayers at non freezing temperatures
Keywords: CYP; CYPs; Preinduced hepatocytes; Hypothermic preservation; Gelatin;
Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2
Keywords: CYP; MBI; mechanism-based inhibition; RMs; reactive metabolites; CYPs; cytochrome P450 enzymes; GSH; reduced glutathione; HLMs; human liver microsomes; NADPH; β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt; MI complex; metabolite
Characterization of the Gly45Asp variant of human cytochrome P450 1A1 using recombinant expression
Keywords: CYP; CHO; Chinese Hamster Ovary; CYPs; cytochromes P450; CYP1A1; cytochrome P450 1A1; dALA; δ-aminolevulinic acid; EDTA; ethylenediaminetetraacetic acid; ER; 7-ethoxyresorufin; EROD; 7-ethoxyresorufin O-dealkylation; EV; empty control vector; ME; β-mercaptoe
Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2)
Keywords: CYP; Cyanotoxin; Cylindrospermopsin; Cell lineage; HepG2; CYPs
FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6
Keywords: CYP; Cyps; cyclophilins; FKBPs; immunophilins; FKBD; FK506-binding domain; ER; rough endoplasmic reticulum; SERCA; sarco-endoplasmic Ca2+-ATPase; IP3Rs; inositol 1,4,5-trisphosphate receptors; IP3; inositol 1,4,5-trisphosphate; TRPC; transient receptor potenti
Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: Role of docosahexaenoic acid
Keywords: CYP; ABZ; albendazole; ABZ-SO; Albendazole sulfoxide; ACN; acetonitrile; ALP; alkaline phosphatase; ANOVA; analysis of variance; AUC; area-under-the-curve; BBB; blood brain barrier; Cmax; maximum concentration; CUR; Curcumin; CYPs; cytochrome P450; DHA; docosa
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
Keywords: CYP; 6PGD; 6-phosphogluconate dehydrogenase; 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; ADP; adenosine diphosphate; ADSCs; adipose-derived stem cells; aP2; fatty-acid binding protein; AREs; antioxidant response elements; ATP; adenosine tri