کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373749 981905 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel
چکیده انگلیسی

Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC50 values less then 0.1 μM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.

Structure–activity relationship of a new class of Kv1.5 inhibitors based on the tetraline scaffold was investigated.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 11, 1 June 2009, Pages 3063–3066
نویسندگان
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