کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373762 981905 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks
چکیده انگلیسی

Novel imidazole frameworks have been identified as potent partial agonists of the α1A adrenergic receptor, with good selectivity over the α1B, α1D and α2A receptor sub-types. Nitrile 28 possessed attractive CNS drug-like properties with good membrane permeability and no P-pg mediated efflux. 28 also possessed excellent solubility, metabolic stability and wide ligand selectivity.

Novel imidazole frameworks have been identified as potent and selective α1A partial agonists with good CNS drug-like properties.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 11, 1 June 2009, Pages 3118–3121
نویسندگان
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